| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aceB | citE1 | rrnAC1965 | rrnAC0690 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | 0.910 |
| aceB | citG | rrnAC1965 | rrnAC0053 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | CitG family protein. | 0.765 |
| aceB | eda | rrnAC1965 | rrnAC3121 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. | 0.910 |
| aceB | fumC | rrnAC1965 | rrnAC0028 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Fumarate hydratase class-II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.842 |
| aceB | maeB | rrnAC1965 | rrnAC1754 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | NAD-dependent malate dehydrogenase. | 0.858 |
| aceB | mch-2 | rrnAC1965 | rrnAC0688 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Unknown; Involved in the methylaspartate cycle. Catalyzes the reversible hydration of mesaconyl-CoA (methylfumaryl-CoA) to yield beta-methylmalyl-CoA ((2R,3S)-beta-methylmalyl-CoA). Belongs to the enoyl-CoA hydratase/isomerase family. | 0.723 |
| aceB | mdh | rrnAC1965 | rrnAC2706 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. | 0.936 |
| aceB | pepC | rrnAC1965 | rrnAC0562 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Phosphoenolpyruvate carboxylase. | 0.858 |
| aceB | rrnB0215 | rrnAC1965 | rrnB0215 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Thioesterase. | 0.732 |
| aceB | spaT | rrnAC1965 | rrnAC1999 | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | Aminotransferase class V. | 0.917 |
| citE1 | aceB | rrnAC0690 | rrnAC1965 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | 0.910 |
| citE1 | citG | rrnAC0690 | rrnAC0053 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | CitG family protein. | 0.734 |
| citE1 | eda | rrnAC0690 | rrnAC3121 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. | 0.900 |
| citE1 | maeB | rrnAC0690 | rrnAC1754 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | NAD-dependent malate dehydrogenase. | 0.403 |
| citE1 | mch-2 | rrnAC0690 | rrnAC0688 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | Unknown; Involved in the methylaspartate cycle. Catalyzes the reversible hydration of mesaconyl-CoA (methylfumaryl-CoA) to yield beta-methylmalyl-CoA ((2R,3S)-beta-methylmalyl-CoA). Belongs to the enoyl-CoA hydratase/isomerase family. | 0.993 |
| citE1 | spaT | rrnAC0690 | rrnAC1999 | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | Aminotransferase class V. | 0.917 |
| citG | aceB | rrnAC0053 | rrnAC1965 | CitG family protein. | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | 0.765 |
| citG | citE1 | rrnAC0053 | rrnAC0690 | CitG family protein. | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | 0.734 |
| eda | aceB | rrnAC3121 | rrnAC1965 | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. | Malate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. | 0.910 |
| eda | citE1 | rrnAC3121 | rrnAC0690 | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. | Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate. | 0.900 |