STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceBMalate synthase; Involved in the methylaspartate cycle. Catalyzes the biosynthesis of malate in two steps. In the first reaction acetyl-CoA is condensed reversibly with glyoxylate to form (S)-malyl-CoA. In the second reaction (S)-malyl-CoA is hydrolyzed to malate and CoA. It can also catalyzes the condensation of propionyl-CoA with glyoxylate and of acetyl-CoA with pyruvate, however the CoA-ester hydrolysis reaction is highly specific for (S)-malyl-CoA. (435 aa)    
Predicted Functional Partners:
mdh
L-malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
  
 
 0.936
spaT
Aminotransferase class V.
    
 0.917
citE1
Citrate lyase beta chain; Involved in the methylaspartate cycle. Catalyzes the reversible cleavage of beta-methylmalyl-CoA to propionyl-CoA and glyoxylate, as well as the reversible cleavage of (S)-malyl-CoA to acetyl-CoA and glyoxylate. In addition, it has a small malyl-CoA thioesterase activity. It can also catalyzes the cleavage of (S)- citramalyl-CoA to acetyl-CoA and pyruvate.
  
  
 
0.910
eda
2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase.
     
 0.910
pepC
Phosphoenolpyruvate carboxylase.
    
 0.858
maeB
NAD-dependent malate dehydrogenase.
  
 
 0.858
fumC
Fumarate hydratase class-II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
  0.842
citG
CitG family protein.
 
  
 0.765
rrnB0215
Thioesterase.
      
 0.732
mch-2
Unknown; Involved in the methylaspartate cycle. Catalyzes the reversible hydration of mesaconyl-CoA (methylfumaryl-CoA) to yield beta-methylmalyl-CoA ((2R,3S)-beta-methylmalyl-CoA). Belongs to the enoyl-CoA hydratase/isomerase family.
  
  
 0.723
Your Current Organism:
Haloarcula marismortui
NCBI taxonomy Id: 272569
Other names: H. marismortui ATCC 43049, Haloarcula marismortui ATCC 43049, Haloarcula marismortui str. ATCC 43049, Haloarcula marismortui strain ATCC 43049
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