node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
kaiC2 | ppnK | rrnAC3392 | rrnAC3391 | Circadian regulator. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.777 |
lpdA1 | lpdA3 | rrnAC3381 | rrnB0197 | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Dihydrolipoamide dehydrogenase. | 0.625 |
lpdA1 | ppnK | rrnAC3381 | rrnAC3391 | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.666 |
lpdA2 | lpdA3 | rrnAC2953 | rrnB0197 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.902 |
lpdA2 | ppnK | rrnAC2953 | rrnAC3391 | Dihydrolipoamide dehydrogenase. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.666 |
lpdA3 | lpdA1 | rrnB0197 | rrnAC3381 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.625 |
lpdA3 | lpdA2 | rrnB0197 | rrnAC2953 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.902 |
lpdA3 | ppnK | rrnB0197 | rrnAC3391 | Dihydrolipoamide dehydrogenase. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.666 |
nadE1 | nadM | rrnAC2486 | rrnAC1913 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinamide-nucleotide adenylyltransferase. | 0.966 |
nadE1 | ppnK | rrnAC2486 | rrnAC3391 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.931 |
nadE1 | rrnAC0727 | rrnAC2486 | rrnAC0727 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | ATP-NAD kinase. | 0.931 |
nadE1 | rrnAC0821 | rrnAC2486 | rrnAC0821 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | ATP-NAD kinase. | 0.900 |
nadE1 | sir2 | rrnAC2486 | rrnAC0470 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Transcriptional regulator Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. | 0.949 |
nadM | nadE1 | rrnAC1913 | rrnAC2486 | Nicotinamide-nucleotide adenylyltransferase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.966 |
nadM | ppnK | rrnAC1913 | rrnAC3391 | Nicotinamide-nucleotide adenylyltransferase. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.920 |
nadM | rrnAC0727 | rrnAC1913 | rrnAC0727 | Nicotinamide-nucleotide adenylyltransferase. | ATP-NAD kinase. | 0.929 |
nadM | rrnAC0821 | rrnAC1913 | rrnAC0821 | Nicotinamide-nucleotide adenylyltransferase. | ATP-NAD kinase. | 0.914 |
nadM | sir2 | rrnAC1913 | rrnAC0470 | Nicotinamide-nucleotide adenylyltransferase. | Transcriptional regulator Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. | 0.971 |
ppnK | kaiC2 | rrnAC3391 | rrnAC3392 | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Circadian regulator. | 0.777 |
ppnK | lpdA1 | rrnAC3391 | rrnAC3381 | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.666 |