node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
entF | ssuD | KPN_00605 | KPN_00971 | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | 0.831 |
entF | ssuD-2 | KPN_00605 | KPN_03147 | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | 0.831 |
entF | ycdH | KPN_00605 | KPN_01033 | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | Putative flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.707 |
entF | ycdM | KPN_00605 | KPN_01038 | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | Putative enzyme; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.840 |
hpaB | ycdH | KPN_04780 | KPN_01033 | 4-hydroxyphenylacetate catabolism. | Putative flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.715 |
ssuD | entF | KPN_00971 | KPN_00605 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | 0.831 |
ssuD | ssuD-2 | KPN_00971 | KPN_03147 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | 0.655 |
ssuD | ycdH | KPN_00971 | KPN_01033 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Putative flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.775 |
ssuD | ycdI | KPN_00971 | KPN_01034 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Hypothetical protein; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. | 0.401 |
ssuD | ycdL | KPN_00971 | KPN_01037 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Hypothetical isochorismatase family protein; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.427 |
ssuD | ycdM | KPN_00971 | KPN_01038 | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Putative enzyme; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.597 |
ssuD-2 | entF | KPN_03147 | KPN_00605 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | ATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. | 0.831 |
ssuD-2 | ssuD | KPN_03147 | KPN_00971 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Putative alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | 0.655 |
ssuD-2 | ycdH | KPN_03147 | KPN_01033 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Putative flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.776 |
ssuD-2 | ycdI | KPN_03147 | KPN_01034 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Hypothetical protein; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. | 0.400 |
ssuD-2 | ycdL | KPN_03147 | KPN_01037 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Hypothetical isochorismatase family protein; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. | 0.426 |
ssuD-2 | ycdM | KPN_03147 | KPN_01038 | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. | Putative enzyme; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. | 0.596 |
ycdG | ycdH | KPN_01032 | KPN_01033 | Putative transport protein. | Putative flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. | 0.728 |
ycdG | ycdI | KPN_01032 | KPN_01034 | Putative transport protein. | Hypothetical protein; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. | 0.857 |
ycdG | ycdJ | KPN_01032 | KPN_01035 | Putative transport protein. | Putative hydrolase; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. | 0.821 |