node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KPN_02220 | cysG | KPN_02220 | KPN_03115 | Putative nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.896 |
KPN_02220 | cysG-2 | KPN_02220 | KPN_03754 | Putative nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.899 |
KPN_02220 | cysH | KPN_02220 | KPN_03117 | Putative nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.824 |
KPN_02220 | cysI | KPN_02220 | KPN_03118 | Putative nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.833 |
KPN_02220 | hemC | KPN_02220 | KPN_04304 | Putative nitrite reductase [NAD(P)H] large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.469 |
cbiG | cbiH | KPN_03193 | KPN_03192 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | 0.999 |
cbiG | cbiK | KPN_03193 | KPN_03190 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.997 |
cbiG | cysG | KPN_03193 | KPN_03115 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.896 |
cbiG | cysG-2 | KPN_03193 | KPN_03754 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.904 |
cbiG | cysI | KPN_03193 | KPN_03118 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.720 |
cbiG | hemB | KPN_03193 | KPN_00316 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.414 |
cbiG | hemC | KPN_03193 | KPN_04304 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.489 |
cbiH | cbiG | KPN_03192 | KPN_03193 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | 0.999 |
cbiH | cbiK | KPN_03192 | KPN_03190 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.991 |
cbiH | cysG | KPN_03192 | KPN_03115 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Siroheme synthetase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.889 |
cbiH | cysG-2 | KPN_03192 | KPN_03754 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.891 |
cbiH | cysI | KPN_03192 | KPN_03118 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Sulfite reductase, alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.757 |
cbiH | hemB | KPN_03192 | KPN_00316 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.478 |
cbiH | hemC | KPN_03192 | KPN_04304 | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.475 |
cbiK | cbiG | KPN_03190 | KPN_03193 | Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | Hypothetical protein; Synthesis of vitamin B12 adenosyl cobalamide precursor. | 0.997 |