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ileS protein (Lactobacillus acidophilus NCFM) - STRING interaction network
"ileS" - Isoleucine--tRNA ligase in Lactobacillus acidophilus NCFM
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile); Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily (927 aa)    
Predicted Functional Partners:
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (879 aa)
 
 
  0.977
serS
Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (435 aa)
 
   
  0.956
leuS
Leucine--tRNA ligase; LeuS; COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family (804 aa)
   
 
0.922
LBA0819
Putative ADP-ribose pyrophosphatase; MutT (189 aa)
   
        0.921
valS
Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily (879 aa)
 
 
0.902
lysS
annotation not available (516 aa)
 
 
  0.878
argS
Arginine--tRNA ligase; ArgS; COG0018 Arginyl-tRNA synthetase (561 aa)
   
 
  0.873
cysS
Cysteine--tRNA ligase; COG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family (477 aa)
   
   
  0.873
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1213 aa)
   
 
  0.871
LBA0818
Putative cold-shock protein; COG1278 Cold shock protein (67 aa)
   
        0.867
Your Current Organism:
Lactobacillus acidophilus NCFM
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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