node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpE | groL | LBA0638 | LBA0406 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.863 |
clpE | groS | LBA0638 | LBA0405 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.852 |
clpE | grpE | LBA0638 | LBA1248 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin, Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] | 0.853 |
clpE | hslO | LBA0638 | LBA0279 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Heat-shock protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.480 |
clpE | hslU | LBA0638 | LBA0985 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | ATP dependant protease, ATP binding unit, heatshock protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.771 |
clpE | hslV | LBA0638 | LBA0984 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent heat shock protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.758 |
clpE | topA | LBA0638 | LBA0981 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.516 |
clpE-2 | groL | LBA1910 | LBA0406 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.853 |
clpE-2 | groS | LBA1910 | LBA0405 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.852 |
clpE-2 | grpE | LBA1910 | LBA1248 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin, Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] | 0.824 |
clpE-2 | hslO | LBA1910 | LBA0279 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Heat-shock protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.481 |
clpE-2 | hslU | LBA1910 | LBA0985 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | ATP dependant protease, ATP binding unit, heatshock protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.770 |
clpE-2 | hslV | LBA1910 | LBA0984 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent heat shock protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.756 |
clpE-2 | topA | LBA1910 | LBA0981 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.516 |
gidA | hslU | LBA0982 | LBA0985 | Glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | ATP dependant protease, ATP binding unit, heatshock protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.875 |
gidA | hslV | LBA0982 | LBA0984 | Glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | ATP-dependent heat shock protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.873 |
gidA | topA | LBA0982 | LBA0981 | Glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.930 |
gidA | xerC | LBA0982 | LBA0983 | Glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | Integrase-recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.885 |
groL | clpE | LBA0406 | LBA0638 | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | 0.863 |
groL | clpE-2 | LBA0406 | LBA1910 | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | 0.853 |