node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CarB | LBA1150 | LBA1149 | LBA1150 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Carbamoyl-phosphate synthase small subunit. | 0.999 |
CarB | LBA1151 | LBA1149 | LBA1151 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.826 |
CarB | lspA | LBA1149 | LBA1152 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Lipoprotein signal peptidase A; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.820 |
CarB | purU | LBA1149 | LBA1153 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Formate-tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.811 |
LBA1150 | CarB | LBA1150 | LBA1149 | Carbamoyl-phosphate synthase small subunit. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.999 |
LBA1150 | LBA1151 | LBA1150 | LBA1151 | Carbamoyl-phosphate synthase small subunit. | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.820 |
LBA1150 | lspA | LBA1150 | LBA1152 | Carbamoyl-phosphate synthase small subunit. | Lipoprotein signal peptidase A; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.820 |
LBA1150 | purH | LBA1150 | LBA1552 | Carbamoyl-phosphate synthase small subunit. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PurH. | 0.636 |
LBA1150 | purU | LBA1150 | LBA1153 | Carbamoyl-phosphate synthase small subunit. | Formate-tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.795 |
LBA1151 | CarB | LBA1151 | LBA1149 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.826 |
LBA1151 | LBA1150 | LBA1151 | LBA1150 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Carbamoyl-phosphate synthase small subunit. | 0.820 |
LBA1151 | lspA | LBA1151 | LBA1152 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Lipoprotein signal peptidase A; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.930 |
LBA1151 | purU | LBA1151 | LBA1153 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Formate-tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.828 |
dfrA | fhs2 | LBA0902 | LBA1562 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.925 |
dfrA | folD | LBA0902 | LBA1332 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.412 |
dfrA | glyA | LBA0902 | LBA0261 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
dfrA | purH | LBA0902 | LBA1552 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PurH. | 0.924 |
dfrA | purN | LBA0902 | LBA1553 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosyl glycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
dfrA | purU | LBA0902 | LBA1153 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. | 0.925 |
fhs2 | dfrA | LBA1562 | LBA0902 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.925 |