node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LBA0470 | mutM | LBA0470 | LBA1549 | COG1201 Lhr-like helicases. | formamidopyrimidine-DNA glycosylase Fpg; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.603 |
LBA0470 | uvrC | LBA0470 | LBA0946 | COG1201 Lhr-like helicases. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.474 |
coaE | dnaB-2 | LBA1548 | LBA1545 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Chromosome replication initiation; DnaB. | 0.874 |
coaE | dnaI | LBA1548 | LBA1544 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | 0.877 |
coaE | mutM | LBA1548 | LBA1549 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | formamidopyrimidine-DNA glycosylase Fpg; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.996 |
coaE | nrdR | LBA1548 | LBA1546 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Putative transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.881 |
coaE | nth | LBA1548 | LBA1160 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.522 |
coaE | polA | LBA1548 | LBA1550 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.965 |
coaE | thrS | LBA1548 | LBA1543 | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | theronyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.602 |
dnaB-2 | coaE | LBA1545 | LBA1548 | Chromosome replication initiation; DnaB. | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.874 |
dnaB-2 | dnaI | LBA1545 | LBA1544 | Chromosome replication initiation; DnaB. | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | 0.958 |
dnaB-2 | mutM | LBA1545 | LBA1549 | Chromosome replication initiation; DnaB. | formamidopyrimidine-DNA glycosylase Fpg; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.927 |
dnaB-2 | nrdR | LBA1545 | LBA1546 | Chromosome replication initiation; DnaB. | Putative transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.932 |
dnaB-2 | polA | LBA1545 | LBA1550 | Chromosome replication initiation; DnaB. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.902 |
dnaB-2 | thrS | LBA1545 | LBA1543 | Chromosome replication initiation; DnaB. | theronyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.627 |
dnaI | coaE | LBA1544 | LBA1548 | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | Dephospho-coa kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.877 |
dnaI | dnaB-2 | LBA1544 | LBA1545 | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | Chromosome replication initiation; DnaB. | 0.958 |
dnaI | mutM | LBA1544 | LBA1549 | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | formamidopyrimidine-DNA glycosylase Fpg; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.912 |
dnaI | nrdR | LBA1544 | LBA1546 | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | Putative transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.867 |
dnaI | polA | LBA1544 | LBA1550 | Primosome component (helicase loader); DnaI; COG1484 DNA replication protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.935 |