STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rlmD23S rRNA (uracil-5-)methyltransferase RumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (444 aa)    
Predicted Functional Partners:
relA
GTP pyrophosphokinase ((p)ppGpp synthetase I) stringent stress response RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
 
     0.840
lpg1455
Phospholipase C.
       0.554
trmB
S-adenosylmethionine-dependent methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
  
 0.516
rlmB
tRNA/rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
 
  
 0.505
lpg2593
rRNA methyltransferase (SUN protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.496
lysU
Lysine tRNA synthetase, heat inducible; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
  
 0.495
rlmL
Hypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.
  
  
 0.483
lpg1454
Multidrug efflux protein.
       0.481
lpg0626
DNA uptake/competence protein ComA.
 
     0.456
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.453
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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