STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
legC5Coiled-coil-containing protein; Conserved gene; similar to surface antigen of Plasmodium and Entamoeba. (865 aa)    
Predicted Functional Partners:
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
   
 
  0.656
legU2
UBOX-containing protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Acts in conjunction with host E2 ubiquitin-conjugating enzymes UBE2D1 (UBCH5A) or UBE2D3 (UBCH5C), and mediates polyubiquitination of host kinase CLK1.
  
     0.588
legL5
Leucine-rich repeat-containing protein; FLJ00180 protein; conserved gene.
  
     0.544
legL3
Leucine-rich repeat-containing protein.
  
     0.503
legS1
Acid sphingomyelinase-like phosphodiesterase.
  
     0.481
lpg2224
UVB-resistance protein UVR8.
  
     0.471
lpg1489
Hypothetical protein.
       0.438
lpg1119
Major acid phosphatase; Conserved gene, eukaryotic gene Map, similar to Drosophila acid phosphatase-1.
  
     0.435
legG1
UVB-resistance protein UVR8; Conserved gene; RCC-1.
  
     0.432
lpg1487
Acetyltransferase, GNAT family.
       0.422
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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