STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
legAS4Eukaryotic huntingtin interacting protein B; Conserved gene, HYP-B; contains ankyrin repeats and SET. (545 aa)    
Predicted Functional Partners:
bcp
Acetylpolyamine aminohydolase.
  
 0.962
atpD
ATP synthase F1, beta chain.
    
 0.955
atpD-2
H+-transporting two-sector ATPase, ATP synthase F1 subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
    
 0.955
lpg1042
Hypothetical protein.
    
  0.899
dnaJ
Heat shock protein DnaJ, chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interact [...]
    
  0.899
cbpA
Curved DNA binding protein DnaJ.
    
  0.899
yjeA
Endo-1,4-beta-xylanase-like.
  
 
 0.888
lpg1665
Hypothetical protein.
  
 
  0.877
legS1
Acid sphingomyelinase-like phosphodiesterase.
  
 
 0.838
lpg0735
DNA helicase, SNF2/RAD54 family domain protein.
   
 0.803
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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