STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dlpADlpA protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (615 aa)    
Predicted Functional Partners:
lpg2681
4-hydroxy-2-oxovalerate aldolase.
 
 0.975
icd
Isocitrate dehydrogenase, NADP-dependent.
 
0.972
mvaB
hydroxymethylglutaryl-CoA lyase.
  
 0.948
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
 
  
 0.947
mdlC
Benzoylformate decarboxylase; Belongs to the TPP enzyme family.
  
 0.857
acnA
Aconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein. Could catalyze the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate (By similarity).
 
 0.857
lpg1820
Hypothetical protein.
  
 0.857
lpg2684
Hypothetical protein.
 
     0.847
sdhA-2
Succinate dehydrogenase flavoprotein subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 0.835
lpg2682
Hypothetical with two candidate membrane-spanning segments.
       0.817
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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