node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
frr | pyrH | lin1351 | lin1350 | Highly similar to ribosome recycling factors; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another | Highly similar to uridylate kinases; Catalyzes the reversible phosphorylation of UMP to UDP | 0.971 |
frr | recA | lin1351 | lin1435 | Highly similar to ribosome recycling factors; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another | Recombination protein reca; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.817 |
frr | tsf | lin1351 | lin1766 | Highly similar to ribosome recycling factors; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another | Translation elongation factor; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome | 0.964 |
frr | uppS | lin1351 | lin1352 | Highly similar to ribosome recycling factors; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another | Similar to undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids | 0.838 |
guaA | ndk | lin1081 | lin2043 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Similar to nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | 0.663 |
guaA | pyrF | lin1081 | lin1946 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | 0.846 |
guaA | pyrH | lin1081 | lin1350 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Highly similar to uridylate kinases; Catalyzes the reversible phosphorylation of UMP to UDP | 0.865 |
guaA | pyrR | lin1081 | lin1954 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Bifunctional pyrimidine regulatory protein pyrr uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes | 0.764 |
guaA | recA | lin1081 | lin1435 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Recombination protein reca; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.779 |
guaA | tsf | lin1081 | lin1766 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Translation elongation factor; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome | 0.675 |
guaA | udk | lin1081 | lin1532 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Similar to Uridine kinase; functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor | 0.684 |
guaA | upp | lin1081 | lin2682 | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | Highly similar to uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate | 0.689 |
ndk | guaA | lin2043 | lin1081 | Similar to nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.663 |
ndk | pyrH | lin2043 | lin1350 | Similar to nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate | Highly similar to uridylate kinases; Catalyzes the reversible phosphorylation of UMP to UDP | 0.943 |
pyrF | guaA | lin1946 | lin1081 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Gmp synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP | 0.846 |
pyrF | pyrH | lin1946 | lin1350 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Highly similar to uridylate kinases; Catalyzes the reversible phosphorylation of UMP to UDP | 0.949 |
pyrF | pyrR | lin1946 | lin1954 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Bifunctional pyrimidine regulatory protein pyrr uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes | 0.987 |
pyrF | recA | lin1946 | lin1435 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Recombination protein reca; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage | 0.430 |
pyrF | udk | lin1946 | lin1532 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Similar to Uridine kinase; functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor | 0.933 |
pyrF | upp | lin1946 | lin2682 | Highly similar to orotidine 5'-phosphate decarboxylases; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) | Highly similar to uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate | 0.971 |