node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
pyrAB | pyrAa | gene:17566307 | gene:17566308 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | 0.999 |
pyrAB | pyrB | gene:17566307 | gene:17566310 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Highly similar to aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
pyrAB | pyrC | gene:17566307 | gene:17566309 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrAB | pyrD | gene:17566307 | gene:17566305 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.997 |
pyrAB | pyrDII | gene:17566307 | gene:17566306 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.994 |
pyrAB | pyrE | gene:17566307 | gene:17566303 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.995 |
pyrAB | pyrF | gene:17566307 | gene:17566304 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.996 |
pyrAB | pyrP | gene:17566307 | gene:17566311 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | PyrP protein; Highly similar to uracil permease. | 0.940 |
pyrAB | pyrR | gene:17566307 | gene:17566312 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.935 |
pyrAB | upp | gene:17566307 | gene:17567062 | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.540 |
pyrAa | pyrAB | gene:17566308 | gene:17566307 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Carbamoyl-phosphate synthase large chain; Highly similar to carbamoyl-phosphate synthetase (catalytic subunit). | 0.999 |
pyrAa | pyrB | gene:17566308 | gene:17566310 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Highly similar to aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
pyrAa | pyrC | gene:17566308 | gene:17566309 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrAa | pyrD | gene:17566308 | gene:17566305 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.985 |
pyrAa | pyrDII | gene:17566308 | gene:17566306 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.978 |
pyrAa | pyrE | gene:17566308 | gene:17566303 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.993 |
pyrAa | pyrF | gene:17566308 | gene:17566304 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.992 |
pyrAa | pyrP | gene:17566308 | gene:17566311 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | PyrP protein; Highly similar to uracil permease. | 0.959 |
pyrAa | pyrR | gene:17566308 | gene:17566312 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.879 |
pyrAa | upp | gene:17566308 | gene:17567062 | Carbamoyl-phosphate synthase small chain; Highly similar to carbamoyl-phosphate synthetase (glutaminase subunit); Belongs to the CarA family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.563 |