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ftfL protein (Methylobacterium extorquens AM1) - STRING interaction network
"ftfL" - Formate--tetrahydrofolate ligase in Methylobacterium extorquens AM1
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ftfLFormate--tetrahydrofolate ligase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the formate--tetrahydrofolate ligase family (557 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (434 aa)
   
  0.986
fch
Methenyltetrahydrofolate cyclohydrolase; Required for both C1 and C2 metabolism; Belongs to the cyclodeaminase/cyclohydrolase family (208 aa)
 
 
  0.983
metH
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme (1250 aa)
       
  0.964
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (219 aa)
   
 
  0.961
gcvT
Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Evidence 2b - Function of strongly homologous gene; Product type e - enzyme (392 aa)
   
 
  0.944
folC
Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the folylpolyglutamate synthase family (441 aa)
 
 
  0.938
dfrA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (166 aa)
   
 
  0.931
purH
Bifunctional purine biosynthesis protein PurH; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme (532 aa)
   
 
  0.899
metF
Methylenetetrahydrofolate reductase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme (310 aa)
   
   
  0.802
purD
Phosphoribosylamine--glycine ligase; Evidence 2a - Function of homologous gene experimentally demonstrated in an other organism; Product type e - enzyme; Belongs to the GARS family (435 aa)
   
   
  0.694
Your Current Organism:
Methylobacterium extorquens AM1
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylobacterium extorquens str. AM1, Methylobacterium extorquens strain AM1, Pseudomonas AM1, Pseudomonas sp. AM1
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