STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pqqCDBifunctional coenzyme PQQ synthesis protein C/D; The PqqC region is involved in ring cyclization and eight- electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo- 4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ. In the C-terminal section; belongs to the PqqD family. (372 aa)    
Predicted Functional Partners:
pqqB
Pyrroloquinoline quinone (PQQ) biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family.
  
 0.988
pqqE
Pyrroloquinoline quinone (PQQ) biosynthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
 
  
 0.987
ACS39590.1
Putative exported protein; Orf3; Function of homologous gene experimentally demonstrated in an other organism; factor.
 
     0.825
ACS39591.1
Hypothetical protein; Function of homologous gene experimentally demonstrated in an other organism; factor.
 
     0.786
xoxF-2
XoxF; Encodes putative PQQ-linked dehydrogenase of unknown specificity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.771
xoxF
XoxF, PQQ-linked dehydrogenase of unknown function; Simiilar to methanol dehydrogenase large subunit lacking methanol dehydrogenase activity; Function of strongly homologous gene; enzyme.
 
  
 0.770
pqqA
Coenzyme PQQ synthesis protein A; Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide. There seems to be another source for PQQ in this bacteria only; Belongs to the PqqA family.
     
 0.770
mxaF
Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH); Catalyzes the oxidation of primary alcohols including methanol; Belongs to the bacterial PQQ dehydrogenase family.
 
  
 0.761
exa
Quinoprotein ethanol dehydrogenase precursor (QEDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.721
ACS42577.1
Putative Quinoprotein alcohol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 0.693
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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