STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
fae-2Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. (170 aa)    
Predicted Functional Partners:
mtdB
NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT.
 
  
 0.994
mtdA
NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency.
 
  
 0.993
fhcD
Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family.
 
  
 0.986
xoxF
XoxF, PQQ-linked dehydrogenase of unknown function; Simiilar to methanol dehydrogenase large subunit lacking methanol dehydrogenase activity; Function of strongly homologous gene; enzyme.
  
  
 0.970
xoxF-2
XoxF; Encodes putative PQQ-linked dehydrogenase of unknown specificity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
  
 0.970
mch
N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT.
 
   
 0.958
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.954
fae-3
Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme.
  
  
 
0.925
fae
Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme.
  
  
 
0.922
mxaF
Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH); Catalyzes the oxidation of primary alcohols including methanol; Belongs to the bacterial PQQ dehydrogenase family.
  
  
 0.907
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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