node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fae | fae-2 | MexAM1_META1p1339 | MexAM1_META1p1766 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.922 |
fae | fae-3 | MexAM1_META1p1339 | MexAM1_META1p3356 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.915 |
fae | fhcD | MexAM1_META1p1339 | MexAM1_META1p1756 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.978 |
fae | glyA | MexAM1_META1p1339 | MexAM1_META1p3384 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
fae | mch | MexAM1_META1p1339 | MexAM1_META1p1763 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.942 |
fae | mtdA | MexAM1_META1p1339 | MexAM1_META1p1728 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.990 |
fae | mtdB | MexAM1_META1p1339 | MexAM1_META1p1761 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.992 |
fae | mxaF | MexAM1_META1p1339 | MexAM1_META1p4538 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH); Catalyzes the oxidation of primary alcohols including methanol; Belongs to the bacterial PQQ dehydrogenase family. | 0.895 |
fae | xoxF | MexAM1_META1p1339 | MexAM1_META1p1740 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | XoxF, PQQ-linked dehydrogenase of unknown function; Simiilar to methanol dehydrogenase large subunit lacking methanol dehydrogenase activity; Function of strongly homologous gene; enzyme. | 0.964 |
fae | xoxF-2 | MexAM1_META1p1339 | MexAM1_META1p2757 | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | XoxF; Encodes putative PQQ-linked dehydrogenase of unknown specificity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.956 |
fae-2 | fae | MexAM1_META1p1766 | MexAM1_META1p1339 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.922 |
fae-2 | fae-3 | MexAM1_META1p1766 | MexAM1_META1p3356 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Formaldehyde activating enzyme-like protein; Function of strongly homologous gene; putative enzyme. | 0.925 |
fae-2 | fhcD | MexAM1_META1p1766 | MexAM1_META1p1756 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.986 |
fae-2 | glyA | MexAM1_META1p1766 | MexAM1_META1p3384 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
fae-2 | mch | MexAM1_META1p1766 | MexAM1_META1p1763 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.958 |
fae-2 | mtdA | MexAM1_META1p1766 | MexAM1_META1p1728 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.993 |
fae-2 | mtdB | MexAM1_META1p1766 | MexAM1_META1p1761 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.994 |
fae-2 | mxaF | MexAM1_META1p1766 | MexAM1_META1p4538 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH); Catalyzes the oxidation of primary alcohols including methanol; Belongs to the bacterial PQQ dehydrogenase family. | 0.907 |
fae-2 | xoxF | MexAM1_META1p1766 | MexAM1_META1p1740 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | XoxF, PQQ-linked dehydrogenase of unknown function; Simiilar to methanol dehydrogenase large subunit lacking methanol dehydrogenase activity; Function of strongly homologous gene; enzyme. | 0.970 |
fae-2 | xoxF-2 | MexAM1_META1p1766 | MexAM1_META1p2757 | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | XoxF; Encodes putative PQQ-linked dehydrogenase of unknown specificity; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.970 |