STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACS41185.1Putative ATP-dependent DNA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (635 aa)    
Predicted Functional Partners:
ACS41184.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 0.994
dnaN
DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.957
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.932
dnlJ
DNA ligase, NAD(+)-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
    
 0.925
ACS41105.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
 
   
 0.839
ACS41186.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
       0.800
ACS41104.1
ATP-dependent DNA helicase; Function of strongly homologous gene; enzyme.
 
    0.796
sbcC
Nuclease sbcCD subunit C; Function of strongly homologous gene; enzyme.
   
 0.657
xthA
Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme.
  
 
 0.649
xthA-2
Exodeoxyribonuclease III (Exonuclease III) (EXO III) (AP endonuclease VI); Function of strongly homologous gene; enzyme.
  
 
 0.649
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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