node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39663.1 | ACS41949.1 | MexAM1_META1p1821 | MexAM1_META1p4313 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Short-chain dehydrogenase/reductase SDR; Function of strongly homologous gene; enzyme. | 0.541 |
ACS39663.1 | aroB | MexAM1_META1p1821 | MexAM1_META1p1535 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.545 |
ACS39663.1 | dfrA | MexAM1_META1p1821 | MexAM1_META1p2852 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.426 |
ACS39663.1 | dmrA | MexAM1_META1p1821 | MexAM1_META1p4312 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Dihydromethanopterin reductase; Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Shows preference for NADPH rather than NADH as electron donor. Does not reduce dihydrofolate. | 0.426 |
ACS39663.1 | glyA | MexAM1_META1p1821 | MexAM1_META1p3384 | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.516 |
ACS41949.1 | ACS39663.1 | MexAM1_META1p4313 | MexAM1_META1p1821 | Short-chain dehydrogenase/reductase SDR; Function of strongly homologous gene; enzyme. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.541 |
ACS41949.1 | dmrA | MexAM1_META1p4313 | MexAM1_META1p4312 | Short-chain dehydrogenase/reductase SDR; Function of strongly homologous gene; enzyme. | Dihydromethanopterin reductase; Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Shows preference for NADPH rather than NADH as electron donor. Does not reduce dihydrofolate. | 0.624 |
ACS41949.1 | purF | MexAM1_META1p4313 | MexAM1_META1p4314 | Short-chain dehydrogenase/reductase SDR; Function of strongly homologous gene; enzyme. | Amidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.797 |
ACS41949.1 | ubiE | MexAM1_META1p4313 | MexAM1_META1p4311 | Short-chain dehydrogenase/reductase SDR; Function of strongly homologous gene; enzyme. | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.444 |
aroB | ACS39663.1 | MexAM1_META1p1535 | MexAM1_META1p1821 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.545 |
aroB | dfrA | MexAM1_META1p1535 | MexAM1_META1p2852 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.453 |
aroB | dmrA | MexAM1_META1p1535 | MexAM1_META1p4312 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Dihydromethanopterin reductase; Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Shows preference for NADPH rather than NADH as electron donor. Does not reduce dihydrofolate. | 0.453 |
aroB | glyA | MexAM1_META1p1535 | MexAM1_META1p3384 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.434 |
aroB | thyA | MexAM1_META1p1535 | MexAM1_META1p2853 | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.501 |
czcA-2 | dfrA | MexAM1_META1p2655 | MexAM1_META1p2852 | Cobalt-zinc-cadmium resistance protein czcA (Cation efflux system protein czcA); Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.448 |
czcA-2 | dmrA | MexAM1_META1p2655 | MexAM1_META1p4312 | Cobalt-zinc-cadmium resistance protein czcA (Cation efflux system protein czcA); Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Dihydromethanopterin reductase; Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Shows preference for NADPH rather than NADH as electron donor. Does not reduce dihydrofolate. | 0.448 |
dfrA | ACS39663.1 | MexAM1_META1p2852 | MexAM1_META1p1821 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Putative fatty acid synthase multidomain protein (rkpA-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.426 |
dfrA | aroB | MexAM1_META1p2852 | MexAM1_META1p1535 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.453 |
dfrA | czcA-2 | MexAM1_META1p2852 | MexAM1_META1p2655 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Cobalt-zinc-cadmium resistance protein czcA (Cation efflux system protein czcA); Function of homologous gene experimentally demonstrated in an other organism; transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.448 |
dfrA | dmrA | MexAM1_META1p2852 | MexAM1_META1p4312 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydromethanopterin reductase; Catalyzes the reduction of dihydromethanopterin (H(2)MPT) to tetrahydromethanopterin (H(4)MPT). Shows preference for NADPH rather than NADH as electron donor. Does not reduce dihydrofolate. | 0.677 |