node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38498.1 | cysG | MexAM1_META1p0559 | MexAM1_META1p3434 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.957 |
ACS38498.1 | hemB | MexAM1_META1p0559 | MexAM1_META1p4633 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Function of strongly homologous gene; enzyme; Belongs to the ALAD family. | 0.880 |
ACS38498.1 | hemC | MexAM1_META1p0559 | MexAM1_META1p5307 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.988 |
ACS38498.1 | hemE | MexAM1_META1p0559 | MexAM1_META1p1385 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.937 |
ACS41147.1 | hemC | MexAM1_META1p3410 | MexAM1_META1p5307 | NifU-like protein; Function of strongly homologous gene; cell process. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.885 |
bchD | cysG | MexAM1_META1p3217 | MexAM1_META1p3434 | Magnesium chelatase subunit BchD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.508 |
bchD | hemC | MexAM1_META1p3217 | MexAM1_META1p5307 | Magnesium chelatase subunit BchD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.641 |
bchD | hemE | MexAM1_META1p3217 | MexAM1_META1p1385 | Magnesium chelatase subunit BchD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.490 |
cobM | cysG | MexAM1_META1p0804 | MexAM1_META1p3434 | Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.639 |
cobM | hemB | MexAM1_META1p0804 | MexAM1_META1p4633 | Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Function of strongly homologous gene; enzyme; Belongs to the ALAD family. | 0.563 |
cobM | hemC | MexAM1_META1p0804 | MexAM1_META1p5307 | Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.589 |
cysG | ACS38498.1 | MexAM1_META1p3434 | MexAM1_META1p0559 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.957 |
cysG | bchD | MexAM1_META1p3434 | MexAM1_META1p3217 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Magnesium chelatase subunit BchD; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.508 |
cysG | cobM | MexAM1_META1p3434 | MexAM1_META1p0804 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. | 0.639 |
cysG | hemB | MexAM1_META1p3434 | MexAM1_META1p4633 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; Function of strongly homologous gene; enzyme; Belongs to the ALAD family. | 0.933 |
cysG | hemC | MexAM1_META1p3434 | MexAM1_META1p5307 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
cysG | hemE | MexAM1_META1p3434 | MexAM1_META1p1385 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.950 |
cysG | ispB | MexAM1_META1p3434 | MexAM1_META1p3319 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Octaprenyl diphosphate synthase; Function of strongly homologous gene; enzyme; Belongs to the FPP/GGPP synthase family. | 0.414 |
gapA | hemC | MexAM1_META1p2367 | MexAM1_META1p5307 | Glyceraldehyde-3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.757 |
hemB | ACS38498.1 | MexAM1_META1p4633 | MexAM1_META1p0559 | Porphobilinogen synthase; Function of strongly homologous gene; enzyme; Belongs to the ALAD family. | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.880 |