node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0004 | dnaN | gene:17573813 | gene:17573811 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.889 |
ML0004 | gyrA | gene:17573813 | gene:17573815 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.652 |
ML0004 | gyrB | gene:17573813 | gene:17573814 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.763 |
ML0004 | recF | gene:17573813 | gene:17573812 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA replication and SOS induction protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.893 |
ML0633 | gltB | gene:17574454 | gene:17573873 | Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.493 |
ML0633 | recA | gene:17574454 | gene:17574813 | Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.696 |
ML0633 | recF | gene:17574454 | gene:17573812 | Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. | Putative DNA replication and SOS induction protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.803 |
ML0633 | recR | gene:17574454 | gene:17576190 | Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. | DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.981 |
dnaA | dnaN | gene:17573810 | gene:17573811 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.997 |
dnaA | gyrA | gene:17573810 | gene:17573815 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.438 |
dnaA | gyrB | gene:17573810 | gene:17573814 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.772 |
dnaA | recA | gene:17573810 | gene:17574813 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.730 |
dnaA | recF | gene:17573810 | gene:17573812 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA replication and SOS induction protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.905 |
dnaA | recR | gene:17573810 | gene:17576190 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.402 |
dnaA | rnpA | gene:17573810 | gene:17576578 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.794 |
dnaN | ML0004 | gene:17573811 | gene:17573813 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | 0.889 |
dnaN | dnaA | gene:17573811 | gene:17573810 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | 0.997 |
dnaN | gltB | gene:17573811 | gene:17573873 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.422 |
dnaN | gyrA | gene:17573811 | gene:17573815 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.818 |
dnaN | gyrB | gene:17573811 | gene:17573814 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.941 |