STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppiAPutative peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (182 aa)    
Predicted Functional Partners:
ML2355
Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...]
  
 
 0.999
ML2357
Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...]
   
 
 0.952
rhlE
Similar to Mycobacterium tuberculosis putative ATP-dependent RNA helicase Rv3211 or MTCY07D11.15c (407 aa) TR:O05855 (EMBL:Z95120) fasta scores: E(): 0, 74.8% id in 531 aa, and to Klebsiella pneumoniae ATP-dependent RNA helicase deaD SW:DEAD_KLEPN (P33906) fasta scores: E(): 0, 43.2% id in 380 aa. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature.
 
 0.893
htpG
Heat shock protein Hsp90 family; Molecular chaperone. Has ATPase activity.
  
 0.865
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
   
 0.704
atpC
ATP synthase [epsilon] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
  
 0.693
ML0873
Putative carbohydrate kinase; Similar to Mycobacterium tuberculosis hypothetical sugar kinase Rv2202c or MTCY190.13C SW:YM02_MYCTU (Q10391) (324 aa) fasta scores: E(): 0, 83.3% id in 324 aa, and to Streptomyces coelicolor putative kinase SC6G10.31C TR:Q9X816 (EMBL:AL049497) (338 aa) fasta scores: E(): 0, 58.9% id in 319 aa. Shows weak similarity to known kinases e.g. Bacillus subtilis ribokinase rbsK SW:RBSK_BACSU (P36945; P96733) (293 aa) fasta scores: E(): 1.2e-07, 26.1% id in 283 aa. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase. Contains PS00583 pfkB fa [...]
   
  
 0.684
rplB
50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
   0.648
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
   
 
 0.641
fadD9
Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...]
  
 0.620
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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