STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknBPutative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (622 aa)    
Predicted Functional Partners:
ML0021
Similar to M. tuberculosis Rv0019c, hypothetical protein, TR:P71589 and to Streptomyces coelicolor SCH69.14, hypothetical protein, TR:Q9XA20 (EMBL:AL079308) (172 aa); Fasta score E(): 2e-21, 44.4% identity in 171 aa overlap. Previously sequenced as TR:Q50189 (EMBL:Z70722) (155 aa); Fasta score E(): 0, 100.0% identity in 155 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
 
 
 0.999
ML0022
Similar to M. tuberculosis Rv0020c, hypothetical protein, TR:P71590 (EMBL:AL123456) (527 aa); Fasta score E(): 0, 71.9% identity in 531 aa overlap. Previously sequenced as TR:Q50190 (EMBL:Z70722) (463 aa); Fasta score E(): 0, 100.0% identity in 463 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
 
 
 0.999
ML2076
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 17.3 kda protein Rv1827 SW:YI27_MYCTU (Q50606) fasta scores: E(): 0, 87.0% in 161 aa, and to Streptomyces coelicolor hypothetical 28.1 kda protein TR:CAB88880 (EMBL:AL353861) fasta scores: E(): 1.9e-25, 54.6% in 141 aa. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.999
ML0020
Conserved hypothetical protein; Similar to M. tuberculosis ppp, putative protein phosphatase, TR:P71588 (EMBL:AL123456) (514 aa); Fasta score E(): 0, 76.4% identity in 513 aa overlap and to Streptomyces coelicolor SCH69.15, possible protein phosphatase, TR:Q9XA19 (EMBL:AL079308) (515 aa); Fasta score E(): 0, 40.2% identity in 532 aa overlap. Also similar to many other proteins of undefined function. Previously sequenced as TR:Q50188 (EMBL:Z70722) (509 aa); Fasta score E(): 0, 99.6% identity in 509 aa overlap. Contains hydrophobic, possible membrane-spanning region. Proline-rich C-terminus.
 
 
 0.998
rodA
Similar to M. tuberculosis ftsW, cell-division protein, SW:FTSW_MYCTU (P71587) (469 aa); Fasta score E(): 0, 82.3% identity in 469 aa overlap and to Streptomyces coelicolor ftsW, cell-division protein, TR:Q9ZBA6 (EMBL:AL109663) (456 aa); Fasta score E(): 3.3e-25, 32.1% identity in 377 aa overlap. Previously sequenced as SW:FTSW_MYCLE (Q50186) (465 aa); Fasta score E(): 0, 99.6% identity in 465 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW / rodA / [...]
 
 
 0.983
pknA
Putative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins.
 
 
0.979
pbpA
Similar to M. tuberculosis pbpA, penicillin-binding protein, TR:P71586 (EMBL:AL123456) (491 aa); Fasta score E(): 0, 85.7% identity in 490 aa overlap. Also similar to Bacillus subtilis penicillin-binding protein 3, pbpC, SW:PBPC_BACSU (P42971) (668 aa); Fasta score E(): 2.8e-15, 24.5% identity in 444 aa overlap. Previously sequenced as TR:Q50185 (EMBL:Z70722) (474 aa); Fasta score E(): 0, 96.4% identity in 472 aa overlap. Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain; Similar to regi [...]
  
  
 0.974
ag84
Immunogenic protein, antigen 84; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles; Belongs to the DivIVA family.
  
 
 0.938
pknG
Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...]
 
 
0.822
murC
UDP-N-acetyl-muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
  
  
 0.785
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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