STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknAPutative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins. (437 aa)    
Predicted Functional Partners:
ML0020
Conserved hypothetical protein; Similar to M. tuberculosis ppp, putative protein phosphatase, TR:P71588 (EMBL:AL123456) (514 aa); Fasta score E(): 0, 76.4% identity in 513 aa overlap and to Streptomyces coelicolor SCH69.15, possible protein phosphatase, TR:Q9XA19 (EMBL:AL079308) (515 aa); Fasta score E(): 0, 40.2% identity in 532 aa overlap. Also similar to many other proteins of undefined function. Previously sequenced as TR:Q50188 (EMBL:Z70722) (509 aa); Fasta score E(): 0, 99.6% identity in 509 aa overlap. Contains hydrophobic, possible membrane-spanning region. Proline-rich C-terminus.
 
 
 0.994
pbpA
Similar to M. tuberculosis pbpA, penicillin-binding protein, TR:P71586 (EMBL:AL123456) (491 aa); Fasta score E(): 0, 85.7% identity in 490 aa overlap. Also similar to Bacillus subtilis penicillin-binding protein 3, pbpC, SW:PBPC_BACSU (P42971) (668 aa); Fasta score E(): 2.8e-15, 24.5% identity in 444 aa overlap. Previously sequenced as TR:Q50185 (EMBL:Z70722) (474 aa); Fasta score E(): 0, 96.4% identity in 472 aa overlap. Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain; Similar to regi [...]
  
  
 0.990
rodA
Similar to M. tuberculosis ftsW, cell-division protein, SW:FTSW_MYCTU (P71587) (469 aa); Fasta score E(): 0, 82.3% identity in 469 aa overlap and to Streptomyces coelicolor ftsW, cell-division protein, TR:Q9ZBA6 (EMBL:AL109663) (456 aa); Fasta score E(): 3.3e-25, 32.1% identity in 377 aa overlap. Previously sequenced as SW:FTSW_MYCLE (Q50186) (465 aa); Fasta score E(): 0, 99.6% identity in 465 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW / rodA / [...]
 
 
 0.980
ML0021
Similar to M. tuberculosis Rv0019c, hypothetical protein, TR:P71589 and to Streptomyces coelicolor SCH69.14, hypothetical protein, TR:Q9XA20 (EMBL:AL079308) (172 aa); Fasta score E(): 2e-21, 44.4% identity in 171 aa overlap. Previously sequenced as TR:Q50189 (EMBL:Z70722) (155 aa); Fasta score E(): 0, 100.0% identity in 155 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
 
 
 0.980
pknB
Putative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
 
 
0.979
ML2076
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 17.3 kda protein Rv1827 SW:YI27_MYCTU (Q50606) fasta scores: E(): 0, 87.0% in 161 aa, and to Streptomyces coelicolor hypothetical 28.1 kda protein TR:CAB88880 (EMBL:AL353861) fasta scores: E(): 1.9e-25, 54.6% in 141 aa. Contains Pfam match to entry PF00498 FHA, FHA domain.
 
 
 
 0.969
ag84
Immunogenic protein, antigen 84; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles; Belongs to the DivIVA family.
   
 
 0.944
ML0022
Similar to M. tuberculosis Rv0020c, hypothetical protein, TR:P71590 (EMBL:AL123456) (527 aa); Fasta score E(): 0, 71.9% identity in 531 aa overlap. Previously sequenced as TR:Q50190 (EMBL:Z70722) (463 aa); Fasta score E(): 0, 100.0% identity in 463 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
 
 
 0.943
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
      
 0.824
murC
UDP-N-acetyl-muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
   
  
 0.737
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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