STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0151Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. (105 aa)    
Predicted Functional Partners:
aroG
Identical to the previously sequenced Mycobacterium leprae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O69569 (EMBL:AL022602) (462 aa); Fasta score E(): 0, 100.0% identity in 462 aa overlap(EMBL:AL022602). Also highly similar to many others e.g. Mycobacterium tuberculosis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O53512 (EMBL:AL021957) (462 aa); Fasta score E(): 0, 89.7% identity in 465 aa overlap(EMBL:AL021957) and similar to many plant DAHP synthetase family proteins e.g. Arabidopsis thaliana SW:AROF_ARATH (SW:P29976) (525 aa); Fasta score E(): 0, 49.0% iden [...]
   
 
 0.999
aroF
Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.962
ML2472
Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase.
 
 0.946
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.936
pheA
Putative prephenate dehydratase; Similar to M. tuberculosis Rv3838c, pheA, prephenate dehydratase, TR:P96240 (EMBL:AL123456) (321 aa); Fasta score E(): 0, 83.9% identity in 311 aa overlap. Similar to Amycolatopsis methanolica pheA, prephenate dehydratase, SW:PHEA_AMYME (Q44104) (304 aa); Fasta score E(): 0, 44.4% identity in 315 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase. Contains PS00858 Prephenate dehydratase signature 2.
  
 
 0.923
pabA
EC_number=4.1.3.-; Similar to M. tuberculosis pabA, p-aminobenzoate synthase glutamine amidotransferase, TR:Q50183 (EMBL:Z70722) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap (EMBL:AL123456) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap and to Azospirillum brasilense trpG, anthranilate synthase component II, SW:TRPG_AZOBR (P26922) (196 aa); Fasta score E(): 0, 56.1% identity in 187 aa overlap. Previously sequenced as TR:Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferase [...]
  
 
 0.894
entC
Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269.
  
 
 0.875
pabB
EC_number=4.1.3.-; Similar to M. tuberculosis pabB, Rv1005c, putative para-aminobenzoate synthase component I, TR:O05591 (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity in 412 aa overlap. Similar to many e.g. Escherichia coli para-aminobenzoate synthase component I, SW:PABB_ECOLI (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity in 378 aa overlap. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar t [...]
  
 
 0.818
ML0133
Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family.
    
 0.813
acn
Similar to M. tuberculosis aconitate hydratase Rv1475c TR:O53166 (EMBL:AL021184) (943 aa); Fasta score E(): 0, 86.8% identity in 948 aa overlap, and to many others e.g. Bacillus subtilis aconitate hydratase SW:ACON_BACSU (P09339) (908 aa); Fasta score E(): 0, 51.1% identity in 940 aa overlap. Contains 2 Pfam matches to entry PF00330 aconitase, Aconitase family (aconitate hydratase). Contains Pfam match to entry PF00694 Aconitase_C, Aconitase C-terminal domain. Contains PS01244 Aconitase family signature 2. Contains PS00450 Aconitase family signature 1; Similar to and ML1685.
     
 0.804
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.