Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ML0174 | ML0175 | gene:17573989 | gene:17573990 | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.999 |
| ML0174 | ML0176 | gene:17573989 | gene:17573991 | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | 0.584 |
| ML0174 | ML2124 | gene:17573989 | gene:17575977 | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.934 |
| ML0174 | moaB | gene:17573989 | gene:17573992 | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | Similar to M.tuberculosis moaB2, putative molybdenum cofactor biosynthesis protein, TR:O53897 (EMBL:AL123456) (181 aa); Fasta score E(): 0, 92.7% identity in 179 aa overlap. Similar to many e.g. to the C-terminal halves of Arabidopsis thaliana cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis, SW:CNX1_ARATH (Q39054) (670 aa); Fasta score E(): 7.7e-10, 36.4% identity in 187 aa overlap and Synechococcus sp. (strain PCC 7942) moaCB, molybdenum cofactor biosynthesis protein, SW:MOCB_SYNP7 (Q56208) (319 aa); Fasta score E(): 1.3e-09, 35.9% identity in 142 [...] | 0.638 |
| ML0174 | rpmF | gene:17573989 | gene:17573988 | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | Hypothetical protein (pseudogene); Probable ribosomal protein L32, rpmF,similar to many e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap; Belongs to the bacterial ribosomal protein bL32 family. | 0.727 |
| ML0175 | ML0174 | gene:17573990 | gene:17573989 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | 0.999 |
| ML0175 | ML0176 | gene:17573990 | gene:17573991 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | 0.516 |
| ML0175 | ML1681 | gene:17573990 | gene:17575524 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.555 |
| ML0175 | ML2123 | gene:17573990 | gene:17575976 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Two-component response regulator; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Upon phosphorylation by PrrB, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression. Autoregulates its own expression. | 0.921 |
| ML0175 | ML2124 | gene:17573990 | gene:17575977 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.555 |
| ML0175 | ML2439 | gene:17573990 | gene:17576302 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Probable two-component system response regulator; Probably forms part of a two-component regulatory system RegX3/SenX3. | 0.856 |
| ML0175 | moaB | gene:17573990 | gene:17573992 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Similar to M.tuberculosis moaB2, putative molybdenum cofactor biosynthesis protein, TR:O53897 (EMBL:AL123456) (181 aa); Fasta score E(): 0, 92.7% identity in 179 aa overlap. Similar to many e.g. to the C-terminal halves of Arabidopsis thaliana cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis, SW:CNX1_ARATH (Q39054) (670 aa); Fasta score E(): 7.7e-10, 36.4% identity in 187 aa overlap and Synechococcus sp. (strain PCC 7942) moaCB, molybdenum cofactor biosynthesis protein, SW:MOCB_SYNP7 (Q56208) (319 aa); Fasta score E(): 1.3e-09, 35.9% identity in 142 [...] | 0.458 |
| ML0175 | mtrA | gene:17573990 | gene:17574597 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.854 |
| ML0175 | pheT | gene:17573990 | gene:17575241 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap. | 0.493 |
| ML0175 | rpmF | gene:17573990 | gene:17573988 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Hypothetical protein (pseudogene); Probable ribosomal protein L32, rpmF,similar to many e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap; Belongs to the bacterial ribosomal protein bL32 family. | 0.763 |
| ML0176 | ML0174 | gene:17573991 | gene:17573989 | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity). | 0.584 |
| ML0176 | ML0175 | gene:17573991 | gene:17573990 | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.516 |
| ML0176 | moaB | gene:17573991 | gene:17573992 | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | Similar to M.tuberculosis moaB2, putative molybdenum cofactor biosynthesis protein, TR:O53897 (EMBL:AL123456) (181 aa); Fasta score E(): 0, 92.7% identity in 179 aa overlap. Similar to many e.g. to the C-terminal halves of Arabidopsis thaliana cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis, SW:CNX1_ARATH (Q39054) (670 aa); Fasta score E(): 7.7e-10, 36.4% identity in 187 aa overlap and Synechococcus sp. (strain PCC 7942) moaCB, molybdenum cofactor biosynthesis protein, SW:MOCB_SYNP7 (Q56208) (319 aa); Fasta score E(): 1.3e-09, 35.9% identity in 142 [...] | 0.946 |
| ML0176 | rpmF | gene:17573991 | gene:17573988 | Similar to M.tuberculosis Rv0983, probable serine protease, TR:O53896 (EMBL:AL123456) (464 aa); Fasta score E(): 0, 80.7% identity in 383 aa overlap and in part to M.tuberculosis htrA, putative serine protease, TR:O06291 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 41.8% identity in 347 aa overlap. Similar to many e.g. putative serine protease expressed in vivo by Mycobacterium avium subsp. paratuberculosis, TR:Q50320 (EMBL:Z23092) (361 aa); Fasta score E(): 1.1e-19, 35.4% identity in 362 aa overlap. Previously sequenced as TR:Q9Z5G6 (EMBL:AL035500) (452 aa); Fasta score E(): 0, 100.0 [...] | Hypothetical protein (pseudogene); Probable ribosomal protein L32, rpmF,similar to many e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap; Belongs to the bacterial ribosomal protein bL32 family. | 0.667 |
| ML1681 | ML0175 | gene:17575524 | gene:17573990 | Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.555 |
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