node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0202 | ML1119 | gene:17574018 | gene:17574945 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | 0.717 |
ML0202 | dnaN | gene:17574018 | gene:17573811 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.999 |
ML0202 | polA | gene:17574018 | gene:17575220 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.960 |
ML0202 | recA | gene:17574018 | gene:17574813 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.664 |
ML0202 | topA | gene:17574018 | gene:17574016 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.771 |
ML1119 | ML0202 | gene:17574945 | gene:17574018 | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | 0.717 |
ML1119 | dnaN | gene:17574945 | gene:17573811 | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.535 |
ML1119 | polA | gene:17574945 | gene:17575220 | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.993 |
ML1119 | recA | gene:17574945 | gene:17574813 | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.839 |
ML1119 | topA | gene:17574945 | gene:17574016 | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.828 |
dnaN | ML0202 | gene:17573811 | gene:17574018 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | 0.999 |
dnaN | ML1119 | gene:17573811 | gene:17574945 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. | 0.535 |
dnaN | pheT | gene:17573811 | gene:17575241 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap. | 0.590 |
dnaN | polA | gene:17573811 | gene:17575220 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.999 |
dnaN | recA | gene:17573811 | gene:17574813 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.859 |
dnaN | topA | gene:17573811 | gene:17574016 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.792 |
gcvB | rplB | gene:17575924 | gene:17575708 | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.695 |
gcvB | topA | gene:17575924 | gene:17574016 | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] | 0.917 |
pheT | dnaN | gene:17575241 | gene:17573811 | phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.590 |
pheT | polA | gene:17575241 | gene:17575220 | phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.919 |