STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
mesJConserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (323 aa)    
Predicted Functional Partners:
hpt
Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...]
 
  
 0.990
ileS
isoleucyl-tRNA synthase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
  
 0.769
lysX
C-term lysyl-tRNA synthase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysin [...]
   
 
 0.766
metS
Putative methionyl-tRNA synthase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
     
 0.763
ML0211
Putative carboxypeptidase; Similar to M. tuberculosis Rv3627c, possible penicillin-binding protein, TR:O06380 (EMBL:AL123456) (461 aa); Fasta score E(): 0, 76.0% identity in 462 aa overlap. Shows weak similarity to penicillin-binding proteins e.g. Neisseria gonorrhoeae pbp3, penicillin binding protein 3, TR:O85665 (EMBL:AF071224) (469 aa); Fasta score E(): 4.5e-08, 33.1% identity in 163 aa overlap. Similar to putative carboxypeptidases from Streptomyces coelicolor e.g. SCE9.15C, possible penicillin-binding protein, TR:Q9X8I8 (EMBL:AL049841) (459 aa); Fasta score E(): 3.8e-32, 36.3% ide [...]
 
   
 0.714
ML0298
Similar to M. tuberculosis Rv0416, conserved hypothetical protein, TR:P96262 (EMBL:AL123456) (68 aa); Fasta score E(): 5.9e-17, 71.6% identity in 74 aa overlap. Similar to bacterial hypothetical protein e.g. Escherichia coli thiS, hypothetical protein, SW:THIS_ECOLI (O32583) (66 aa); Fasta score E(): 0.41, 32.0% identity in 50 aa overlap. Previously sequenced as TR:Q9ZBL3 (EMBL:AL035159) (74 aa); Fasta score E(): 1.2e-28, 100.0% identity in 74 aa overlap.
  
   0.669
ML0337
Shows weak similarity to periplasmic solute-binding proteins e.g. Synechocystis sp. (strain PCC 6803) mntC, periplasmic-binding protein, TR:Q55280 (EMBL:L34630) (330 aa); Fasta score E(): 0.0001, 26.4% identity in 178 aa overlap. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF01297 Lipoprotein_4, Adhesion lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
     
 0.655
moeZ
Probably involved in molybdopterin biosynthesis; Similar to M. tuberculosis moeZ, Rv3206c, moeB homologue, TR:O05860 (EMBL:AL123456) (392 aa); Fasta score E(): 0, 86.4% identity in 391 aa overlap and to M. tuberculosis moeB, Rv3116, putative molybdopterin biosynthesis protein, TR:O05792 (EMBL:AL123456) (389 aa); Fasta score E(): 0, 57.8% identity in 384 aa overlap. Similar to many e.g. Arabidopsis thaliana cnx5, molybdopterin synthase sulphurylase, TR:Q9ZNW0 (EMBL:AF124160) (464 aa); Fasta score E(): 0, 34.5% identity in 406 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, R [...]
  
 
 0.593
pheT
phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap.
 
   
 0.590
mfd
Putative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
  
 0.534
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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