node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0227 | folB | gene:17574044 | gene:17574042 | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | 0.859 |
ML0227 | folE | gene:17574044 | gene:17574040 | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | 0.863 |
ML0227 | folK | gene:17574044 | gene:17574043 | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | Similar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] | 0.859 |
ML0227 | folP | gene:17574044 | gene:17574041 | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.859 |
ML0227 | ftsH | gene:17574044 | gene:17574039 | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.776 |
folB | ML0227 | gene:17574042 | gene:17574044 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | 0.859 |
folB | folC | gene:17574042 | gene:17575309 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | 0.839 |
folB | folE | gene:17574042 | gene:17574040 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | 0.994 |
folB | folK | gene:17574042 | gene:17574043 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Similar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] | 0.999 |
folB | folP | gene:17574042 | gene:17574041 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.998 |
folB | folP2 | gene:17574042 | gene:17574889 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity). | 0.980 |
folB | ftsH | gene:17574042 | gene:17574039 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.915 |
folC | folB | gene:17575309 | gene:17574042 | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | 0.839 |
folC | folE | gene:17575309 | gene:17574040 | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | 0.874 |
folC | folK | gene:17575309 | gene:17574043 | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | Similar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] | 0.603 |
folC | folP | gene:17575309 | gene:17574041 | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.998 |
folC | folP2 | gene:17575309 | gene:17574889 | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | Dihydropteroate synthase; Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity). | 0.992 |
folE | ML0227 | gene:17574040 | gene:17574044 | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions. | 0.863 |
folE | folB | gene:17574040 | gene:17574042 | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. | 0.994 |
folE | folC | gene:17574040 | gene:17575309 | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. | Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. | 0.874 |