STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
folBPutative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. (132 aa)    
Predicted Functional Partners:
folK
Similar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...]
 
 0.999
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives.
 
 
 0.998
folE
Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2.
 
  
 0.994
folP2
Dihydropteroate synthase; Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity).
 
 
 0.980
ftsH
Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
  
    0.915
ML0227
Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.859
folC
Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2.
  
  
 0.839
panC
Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
     
 0.739
ML0228
Putative membrane protein; Similar to M. tuberculosis Rv3604c, putative membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 59.7% identity in 432 aa overlap. Previously sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta score E(): 0, 100.0% identity in 432 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.713
ML0229
Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap.
       0.646
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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