node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0229 | ML0232 | gene:17574046 | gene:17574049 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.938 |
ML0229 | lysS | gene:17574046 | gene:17574050 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Putative lysyl-tRNA synthase; Similar to M. tuberculosis lysS, Rv3598c, putative lysyl-tRNA synthase, SW:SYK_MYCTU (O06284) (505 aa); Fasta score E(): 0, 85.4% identity in 501 aa overlap. Similar to Escherichia coli lysU, lysyl-tRNA synthase, SW:SYK2_ECOLI (P14825) (504 aa); Fasta score E(): 0, 38.8% identity in 497 aa overlap. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1; Similar to the C-terminal half of ML1393. | 0.839 |
ML0229 | panC | gene:17574046 | gene:17574047 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.976 |
ML0229 | panD | gene:17574046 | gene:17574048 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.877 |
ML0232 | ML0229 | gene:17574049 | gene:17574046 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | 0.938 |
ML0232 | coaA | gene:17574049 | gene:17575806 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | 0.932 |
ML0232 | dfp | gene:17574049 | gene:17574364 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.932 |
ML0232 | lysS | gene:17574049 | gene:17574050 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Putative lysyl-tRNA synthase; Similar to M. tuberculosis lysS, Rv3598c, putative lysyl-tRNA synthase, SW:SYK_MYCTU (O06284) (505 aa); Fasta score E(): 0, 85.4% identity in 501 aa overlap. Similar to Escherichia coli lysU, lysyl-tRNA synthase, SW:SYK2_ECOLI (P14825) (504 aa); Fasta score E(): 0, 38.8% identity in 497 aa overlap. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1; Similar to the C-terminal half of ML1393. | 0.842 |
ML0232 | panC | gene:17574049 | gene:17574047 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.994 |
ML0232 | panD | gene:17574049 | gene:17574048 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.954 |
ML2639 | gabT | gene:17576505 | gene:17574306 | Aldehyde dehydrogenase; Similar to many Prokaryotic and Eukaryotic aldehyde dehydrogenases including: Mycobacterium tuberculosis hypothetical 55.0 kda protein RV0147 TR:P96824 (EMBL:Z92770) fasta scores: E(): 0, 77.1% id in 493 aa and Homo sapiens aldehyde dehydrogenase, dimeric NADP-preferring ALDH3 SW:DHAP_HUMAN (P30838) fasta scores: E(): 0, 44.7% id in 450 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. | Similar to M. tuberculosis gabT, Rv2589, 4-aminobutyrate aminotransferase, SW:GABT_MYCTU (Q50632) (449 aa); Fasta score E(): 0, 83.7% identity in 449 aa overlap. Similar to many e.g. Escherichia coli gabT, 4-aminobutyrate aminotransferase, SW:GABT_ECOLI (P22256) (426 aa); Fasta score E(): 0, 43.1% identity in 422 aa overlap. Previously sequenced as SW:GABT_MYCLE (P40829) (446 aa); Fasta score E(): 0, 99.8% identity in 446 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal- [...] | 0.953 |
ML2639 | panC | gene:17576505 | gene:17574047 | Aldehyde dehydrogenase; Similar to many Prokaryotic and Eukaryotic aldehyde dehydrogenases including: Mycobacterium tuberculosis hypothetical 55.0 kda protein RV0147 TR:P96824 (EMBL:Z92770) fasta scores: E(): 0, 77.1% id in 493 aa and Homo sapiens aldehyde dehydrogenase, dimeric NADP-preferring ALDH3 SW:DHAP_HUMAN (P30838) fasta scores: E(): 0, 44.7% id in 450 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.900 |
ML2639 | panD | gene:17576505 | gene:17574048 | Aldehyde dehydrogenase; Similar to many Prokaryotic and Eukaryotic aldehyde dehydrogenases including: Mycobacterium tuberculosis hypothetical 55.0 kda protein RV0147 TR:P96824 (EMBL:Z92770) fasta scores: E(): 0, 77.1% id in 493 aa and Homo sapiens aldehyde dehydrogenase, dimeric NADP-preferring ALDH3 SW:DHAP_HUMAN (P30838) fasta scores: E(): 0, 44.7% id in 450 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.920 |
cmk | panC | gene:17575209 | gene:17574047 | Cytidylate kinase; Highly similar to several cytidylate kinases (EC 2.7.4.14) including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa); Fasta score E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis RV1712TR:O33211 (EMBL:Z98268) (230 aa); Fasta score E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.903 |
coaA | ML0232 | gene:17575806 | gene:17574049 | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.932 |
coaA | dfp | gene:17575806 | gene:17574364 | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.945 |
coaA | panC | gene:17575806 | gene:17574047 | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.922 |
dfp | ML0232 | gene:17574364 | gene:17574049 | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.932 |
dfp | coaA | gene:17574364 | gene:17575806 | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | 0.945 |
dfp | panC | gene:17574364 | gene:17574047 | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.872 |