STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ML0232Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (274 aa)    
Predicted Functional Partners:
panC
Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 
 0.994
panD
Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
  
  
 0.954
coaD
Probable phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.941
ML0229
Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap.
     
 0.938
dfp
Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.932
coaA
Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
     
 0.932
lysS
Putative lysyl-tRNA synthase; Similar to M. tuberculosis lysS, Rv3598c, putative lysyl-tRNA synthase, SW:SYK_MYCTU (O06284) (505 aa); Fasta score E(): 0, 85.4% identity in 501 aa overlap. Similar to Escherichia coli lysU, lysyl-tRNA synthase, SW:SYK2_ECOLI (P14825) (504 aa); Fasta score E(): 0, 38.8% identity in 497 aa overlap. Contains Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N). Contains PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1; Similar to the C-terminal half of ML1393.
  
  
 0.842
ML0228
Putative membrane protein; Similar to M. tuberculosis Rv3604c, putative membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 59.7% identity in 432 aa overlap. Previously sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta score E(): 0, 100.0% identity in 432 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.736
lsr2
Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...]
       0.668
ftsH
Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
  
    0.647
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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