node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1165 | clpC | gene:17574995 | gene:17574052 | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | 0.859 |
ML1165 | clpP | gene:17574995 | gene:17575318 | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.678 |
ML1165 | clpP2 | gene:17574995 | gene:17575317 | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.625 |
clpC | ML1165 | gene:17574052 | gene:17574995 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.859 |
clpC | clpP | gene:17574052 | gene:17575318 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.981 |
clpC | clpP2 | gene:17574052 | gene:17575317 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.936 |
clpC | clpX | gene:17574052 | gene:17575315 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.796 |
clpC | dnaJ | gene:17574052 | gene:17576358 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.731 |
clpC | dnaJ2 | gene:17574052 | gene:17574446 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | DnaJ homologue; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.731 |
clpC | dnaK | gene:17574052 | gene:17576360 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | 70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.949 |
clpC | grpE | gene:17574052 | gene:17576359 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.889 |
clpC | hsp18 | gene:17574052 | gene:17575642 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | 18 KDA antigen (HSP 16.7); Not known. This protein is one of the major immune reactive proteins in mycobacteria. | 0.719 |
clpC | panD | gene:17574052 | gene:17574048 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.826 |
clpP | ML1165 | gene:17575318 | gene:17574995 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.678 |
clpP | clpC | gene:17575318 | gene:17574052 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | 0.981 |
clpP | clpP2 | gene:17575318 | gene:17575317 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.999 |
clpP | clpX | gene:17575318 | gene:17575315 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.995 |
clpP | dnaJ | gene:17575318 | gene:17576358 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.431 |
clpP | dnaJ2 | gene:17575318 | gene:17574446 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | DnaJ homologue; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.431 |
clpP | dnaK | gene:17575318 | gene:17576360 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 70 kD heat shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.828 |