STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ksgAPutative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (306 aa)    
Predicted Functional Partners:
ML0242
Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
  
 0.995
ML0240
Similar to M. tuberculosis Rv1009, conserved hypothetical protein, TR:O05594 (EMBL:AL123456) (362 aa); Fasta score E(): 0, 82.3% identity in 361 aa overlap. The C-terminus is similar to a region conserved in many bacterial hypothetical proteins e.g. Streptomyces coelicolor SCE87.01C, hypothetical protein, TR:Q9RKD7 (EMBL:AL132674) (330 aa); Fasta score E(): 3.2e-14, 33.8% identity in 225 aa overlap; C-terminus is similar to region of ML2030 and ML2151.
  
  
 0.985
ML0239
Conserved hypothetical protein; Similar to M. tuberculosis ycfH, Rv1008, conserved hypothetical protein, TR:O08343 (EMBL:AL123456) (264 aa); Fasta score E(): 0, 82.3% identity in 260 aa overlap. Similar to many e.g. Bacillus subtilis yabD, conserved hypothetical protein, SW:YABD_BACSU (P37545) (255 aa); Fasta score E(): 0, 41.0% identity in 261 aa overlap. Contains Pfam match to entry PF01026 UPF0006, Metalloenzyme of unknown function. Contains PS01137 Uncharacterized protein family UPF0006 signature 1. Contains PS01091 Uncharacterized protein family UPF0006 signature 3.
  
  
 0.929
rpsJ
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
  
 
 0.889
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
  
 
 0.876
rpsE
30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.874
rpsG
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
 
 0.874
rpsB
Highly similar to many 30s ribosomal proteins (S2) including: Bacillus subtilis SW:RS2_BACSU (P21464) (245 aa); Fasta score E(): 0, 57.6% identity in 250 aa overlap and Mycobacterium tuberculosis RV2890C SW:RS2_MYCTU (Q10796) (287 aa); Fasta score E(): 0, 91.5% identity in 270 aa overlap. Contains Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2. Contains PS00962 Ribosomal protein S2 signature 1; Belongs to the universal ribosomal protein uS2 family.
   
 
 0.867
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
   
 
 0.867
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
   
 
 0.865
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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