STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
purAPutative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b RV0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% id in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% id in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature.
 
 0.997
hpt
Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...]
  
 
 0.983
purH
Similar to M. tuberculosis Rv0957, purH, putative phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.982
guaB2
Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.981
guaB3
Similar to M. tuberculosis guaB3, Rv3410c, putative inosine-5'-monophosphate dehydrogenase, SW:YY10_MYCTU (Q50716) (375 aa); Fasta score E(): 0, 90.5% identity in 368 aa overlap. This ORF is similar in part to ML0387 and ML2066, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera. Previously sequenced as SW:YY10_MYCLE (U00015) (375 aa); Fasta score E(): 0, 100.0% identity in 370 aa overlap. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C term [...]
 
 
 0.964
guaB1
Inosine-5'-monophosphate dehydrogenase; Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IM [...]
  
 
 0.963
pyrB
Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...]
  
 
 0.922
argG
Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2.
  
 
 0.921
asnB
Similar to Mycobacterium tuberculosis putative asparagine synthetase [glutamine-hydrolyzing] Rv2201 or mtcy190.12 SW:ASNH_MYCTU (Q10374) (652 aa) fasta scores: E(): 0, 83.3% id in 659 aa and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 asnB or asn SW:ASNB_BACSU (P54420; O34902) (632 aa) fasta scores: E(): 0, 49.0% id in 614 aa. Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00733 Asn_synthase, Asparagine synthase.
  
 
 0.920
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.907
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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