STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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thiEPutative thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (235 aa)    
Predicted Functional Partners:
thiD
Putative phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
 
 0.999
thiG
Putative thiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.988
thiL
Probable thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.972
ML0298
Similar to M. tuberculosis Rv0416, conserved hypothetical protein, TR:P96262 (EMBL:AL123456) (68 aa); Fasta score E(): 5.9e-17, 71.6% identity in 74 aa overlap. Similar to bacterial hypothetical protein e.g. Escherichia coli thiS, hypothetical protein, SW:THIS_ECOLI (O32583) (66 aa); Fasta score E(): 0.41, 32.0% identity in 50 aa overlap. Previously sequenced as TR:Q9ZBL3 (EMBL:AL035159) (74 aa); Fasta score E(): 1.2e-28, 100.0% identity in 74 aa overlap.
  
  
 0.924
ML0791
Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
 0.906
ML0299
Putative oxidoreductase; Similar to M. tuberculosis Rv0415, conserved hypothetical protein, TR:P96261 (EMBL:AL123456) (340 aa); Fasta score E(): 0, 82.0% identity in 338 aa overlap. Shows weak similarity to Bacillus subtilis goxB, glycine oxidase, SW:GLOX_BACSU (O31616) (369 aa); Fasta score E(): 6.6e-10, 28.7% identity in 352 aa overlap. Previously sequenced as TR:Q9ZBL4 (EMBL:AL035159) (340 aa); Fasta score E(): 0, 100.0% identity in 340 aa overlap. Contains Pfam match to entry PF01266 DAO, D-amino acid oxidase; Shows weak similarity to ML2011.
 
  
 0.809
thiC
Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.795
ML1492
Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
  
  
 0.768
moeZ
Probably involved in molybdopterin biosynthesis; Similar to M. tuberculosis moeZ, Rv3206c, moeB homologue, TR:O05860 (EMBL:AL123456) (392 aa); Fasta score E(): 0, 86.4% identity in 391 aa overlap and to M. tuberculosis moeB, Rv3116, putative molybdopterin biosynthesis protein, TR:O05792 (EMBL:AL123456) (389 aa); Fasta score E(): 0, 57.8% identity in 384 aa overlap. Similar to many e.g. Arabidopsis thaliana cnx5, molybdopterin synthase sulphurylase, TR:Q9ZNW0 (EMBL:AF124160) (464 aa); Fasta score E(): 0, 34.5% identity in 406 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, R [...]
  
  
 0.727
guaB3
Similar to M. tuberculosis guaB3, Rv3410c, putative inosine-5'-monophosphate dehydrogenase, SW:YY10_MYCTU (Q50716) (375 aa); Fasta score E(): 0, 90.5% identity in 368 aa overlap. This ORF is similar in part to ML0387 and ML2066, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera. Previously sequenced as SW:YY10_MYCLE (U00015) (375 aa); Fasta score E(): 0, 100.0% identity in 370 aa overlap. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C term [...]
   
 
 0.724
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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