STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pssASimilar to M. tuberculosis pssA, Rv0436c, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% identity in 285 aa overlap. Similar to many e.g. Helicobacter pylori pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00 [...] (300 aa)    
Predicted Functional Partners:
ML0311
Conserved hypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
 
 
 0.998
ML0979
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identical to the previously sequenced Mycobacterium leprae TR:Q49839 (EMBL:U00019) (193 aa); Fasta score E(): 0, 100.0% identity in 193 aa overlap. Also highly similar to many phosphatidylglycerophosphate synthases including: Mycobacterium tuberculosis Rv2746c TR:O33288 (EMBL:AL008967) (209 aa); Fasta score E(): 0, 77.1% identity in 188 aa overlap and Bacillus subtilis SW:PGSA_BACSU (P46322) (193 aa); Fasta score E(): 5.6e-17, 35.8% identity in 193 aa overlap. Contains multiple possible membrane spanning hydrophobic do [...]
  
 
 0.979
pgsA2
CDP-diacylglycerol-glycerol-3-phosphate; Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature; Similar to and ML0979; Belongs to the CDP-alcohol phosphati [...]
  
 
 0.978
pgsA
Similar to M. tuberculosis pgsA, Rv2612c, putative CDP-alcohol phosphatidyltransferases, TR:O06202 (EMBL:AL123456) (217 aa); Fasta score E(): 0, 79.3% identity in 213 aa overlap. Shows weak similarity to Escherichia coli pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, SW:PGSA_ECOLI (P06978) (738 aa); BlastP Expect 8.6. Previously sequenced as TR:O07149 (EMBL:Z96801) (239 aa); Fasta score E(): 0, 100.0% identity in 239 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyl [...]
  
 
 0.974
ML1589
Possible phosphatidate cytidylyltransferase; The C-terminus of this protein is highly similar to many proteins involved with phospholipid biosynthesis e.g. Escherichia coli phosphatidate cytidylyltransferase (EC 2.7.7.41) SW:CDSA_ECOLI (P06466) (249 aa); Fasta score E(): 6.6e-15, 40.6% identity in 160 aa overlap and Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa); Fasta score E(): 0, 70.3% identity in 313 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferas [...]
    
 0.961
ML1727
Similar in the C-terminus to many phosphoserine phosphatases (EC 3.1.3.3) including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa); Fasta score E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis RV3042C TR:O53289 (EMBL:AL021287) (409 aa); Fasta score E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase.
    
  0.903
ilvA
Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
    
  0.900
trpB
Tryptophan synthase [beta] chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.900
trpA
Tryptophan synthase [alpha] chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.900
ML1417
Similar to several CDP-diacylglycerol pyrophosphatases (EC 3.6.1.26) involved in phospholipid biosynthesis, including: Salmonella typhimurium SW:CDH_SALTY (P26219) (251 aa); Fasta score E(): 1.6e-25, 39.1% identity in 220 aa overlap and Mycobacterium tuberculosis RV2289 SW:CDH_MYCTU (Q50676) (260 aa); Fasta score E(): 0, 66.4% identity in 256 aa overlap.
     
  0.900
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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