STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Experiments
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[Homology]
Score
ML0333Conserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (252 aa)    
Predicted Functional Partners:
ML2550
Conserved hypothetical protein; Similar to many proteins of undefined function including: Mycobacterium tuberculosis hypothetical 32.2 kDa protein RV0263C TR:P95220 (EMBL:Z86089) fasta scores: E(): 0, 78.3% id in 286 aa, and to Escherichia coli hypothetical 34.4 kDa protein in SW:YBGK_ECOLI (P75745) fasta scores: E(): 2.6e-26, 35.5% id in 304 aa.
  
 0.941
ML2549
Conserved hypothetical protein; Similar to several proteins of undefined function including: Mycobacterium tuberculosis hypothetical protein RV0264C TR:P95221 (EMBL:Z86089) fasta scores: E(): 0, 75.2% id in 202 aa, and to Escherichia coli hypothetical protein SW:YBGJ_ECOLI (P75744) fasta scores: E(): 9.5e-20, 40.1% id in 182 aa.
 
  
 0.911
glnA
Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score E(): 0, 91.8% identity in 478 aa overlap and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature; Similar to ML1631.
   
 
  0.802
glnA2
Glutamine synthase class II; Highly similar to many glutamine synthetases (EC 6.3.1.2) including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa); Fasta score E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis RV2222C SW:GLN2_MYCTU (Q10378) (446 aa); Fasta score E(): 0, 93.3% identity in 448 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase; Similar to ML0925.
   
 
  0.802
gltB
Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
     
  0.800
gltD
Similar to M. tuberculosis Rv3858c, gltD, putative NADH-dependent glutamate synthase small subunit, TR:P96219 (EMBL:Al123456) (488 aa); Fasta score E(): 0, 87.7% identity in 488 aa overlap and to many other putative glutamate synthase small subunits e.g. Escherichia coli gltD, glutamate synthase [NADPH] small chain, SW:GLTD_ECOLI (P09832) (471 aa); Fasta score E(): 0, 37.8% identity in 474 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase.
     
  0.800
ML1249
Conserved hypothetical protein; Similar to several proteins of undefined function including: Mycobacterium tuberculosis RV2476C TR:O53203 (EMBL:AL021246) (1624 aa); Fasta score E(): 0, 81.5% identity in 1634 aa overlap and Rickettsia prowazekii TR:Q9ZCI2 (EMBL:AJ235273) (1581 aa); Fasta score E(): 0, 32.9% identity in 1494 aa overlap.
     
  0.800
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
     
  0.800
pknG
Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...]
      
 0.682
ML1096
Putative membrane protein; Highly similar to Mycobacterium tuberculosis Rv1249c TR:O50464 (EMBL:AL021006) (262 aa); Fasta score E(): 0, 67.3% identity in 223 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
      0.678
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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