STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
alrPutative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (388 aa)    
Predicted Functional Partners:
ddlA
D-alanine-D-alanine ligase A; Cell wall formation.
 
 
 0.995
murF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
   
 0.985
ML0377
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).
  
 0.983
ald
Highly similar to many alanine dehydrogenases (EC 1.4.1.1) including: Bacillus sphaericus SW:DHA_BACSH (P175566) (372 aa); Fasta score E(): 0, 53.4% identity in 365 aa overlap and Mycobacterium tuberculosis RV2780 SW:DHA_MYCTU (P30234) (371 aa); Fasta score E(): 0, 85.4% identity in 371 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Contains PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. Contains PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1; Be [...]
  
 
 0.947
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
   
 0.873
ML0376
Putative membrane protein; Unknown function. Contains hydrophobic, possible membrane-spanning region near the N-terminus.
     
 0.860
gcp
Putative O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
       0.859
ML0378
Similar to M. tuberculosis rimI, Rv3420c, putative ribosomal protein S18 acetyltransferase, TR:Q50708 (EMBL:Z77165) (158 aa); Fasta score E(): 0, 72.1% identity in 154 aa overlap in the C-terminus and to M. tuberculosis Rv3421c hypothetical protein, SW:YY21_MYCTU (Q50707) (211 aa); Fasta score E(): 0, 75.6% identity in 205 aa overlap in the N-terminus. Appears to be a fusion of two M. tuberculosis homologues. Similar to many hypothetical acetyltransferases. Previously sequenced as SW:YY21_MYCLE (Q49857) (359 aa); Fasta score E(): 0, 100.0% identity in 359 aa overlap. Contains Pfam matc [...]
 
   
 0.856
ML2502
Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I.
    
 0.814
murD
UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
 
 
 0.716
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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