STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrSthreonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (702 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap.
 
 
 0.944
leuS
leucyl-tRNA synthase; Similar to M. tuberculosis leuS, leucyl-tRNA synthetase, SW:SYL_MYCTU (P71698) (969 aa); Fasta score E(): 0, 83.6% identity in 972 aa overlap and to Bacillus subtilis leuS, leucyl-tRNA synthetase, SW:SYL_BACSU (P36430) (804 aa); Fasta score E(): 0, 45.7% identity in 941 aa overlap. Previously sequenced as SW:SYL_MYCLE (Q50192) (972 aa); Fasta score E(): 0, 99.9% identity in 972 aa overlap. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
  
 
 0.925
rplO
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
 
 0.917
ML0455
Similar to M. tuberculosis Rv2613c, conserved hypothetical protein, TR:O06201 (EMBL:AL123456) (195 aa); Fasta score E(): 0, 84.7% identity in 196 aa overlap. Similar to many HIT-family hypothetical proteins. Previously sequenced as TR:O07150 (EMBL:Z96801) (186 aa); Fasta score E(): 0, 100.0% identity in 186 aa overlap. Contains Pfam match to entry PF01230 HIT, HIT family.
 
   
 0.906
pgsA
Similar to M. tuberculosis pgsA, Rv2612c, putative CDP-alcohol phosphatidyltransferases, TR:O06202 (EMBL:AL123456) (217 aa); Fasta score E(): 0, 79.3% identity in 213 aa overlap. Shows weak similarity to Escherichia coli pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, SW:PGSA_ECOLI (P06978) (738 aa); BlastP Expect 8.6. Previously sequenced as TR:O07149 (EMBL:Z96801) (239 aa); Fasta score E(): 0, 100.0% identity in 239 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyl [...]
  
  
 0.889
ML0452
Putative glycosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
 
   
 0.885
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
  
 
 0.878
ML0453
Similar to M. tuberculosis Rv2611c, conserved hypothetical protein, TR:O06203 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 71.5% identity in 312 aa overlap. Shows weak similarity to putative acyltransferases e.g. Campylobacter jejuni lipid A biosynthesis acyltransferase, TR:AAF31766 (EMBL:AF130984) (295 aa); Fasta score E(): 0.00017, 20.0% identity in 180 aa overlap. previously sequenced as TR:O07148 (EMBL:Z96801) (320 aa); Fasta score E(): 0, 99.7% identity in 320 aa overlap.
     
 0.867
ML0451
Similar to M. tuberculosis Rv2609c, conserved hypothetical protein, TR:O06205 (EMBL:AL123456) (351 aa); Fasta score E(): 0, 77.7% identity in 336 aa overlap. Similar, in part, to hypothetical proteins from Streptomyces coelicolor e.g. SC2E1.17, hypothetical protein, TR:O69888 (EMBL:AL023797) (172 aa); Fasta score E(): 2e-13, 43.3% identity in 150 aa overlap. Previously sequenced as TR:O07146 (EMBL:Z96801) (349 aa); Fasta score E(): 0, 100.0% identity in 349 aa overlap. Contains PS00893 mutT domain signature.
       0.859
infB
Initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
 
 0.857
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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