node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0151 | ML2472 | gene:17573966 | gene:17576335 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | 0.946 |
ML0151 | aroA | gene:17573966 | gene:17574616 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.697 |
ML0151 | aroF | gene:17573966 | gene:17574337 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.962 |
ML0151 | aroK | gene:17573966 | gene:17574338 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.467 |
ML0151 | entC | gene:17573966 | gene:17574633 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.875 |
ML0151 | pabB | gene:17573966 | gene:17574053 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | EC_number=4.1.3.-; Similar to M. tuberculosis pabB, Rv1005c, putative para-aminobenzoate synthase component I, TR:O05591 (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity in 412 aa overlap. Similar to many e.g. Escherichia coli para-aminobenzoate synthase component I, SW:PABB_ECOLI (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity in 378 aa overlap. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar t [...] | 0.818 |
ML0151 | trpE | gene:17573966 | gene:17575101 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.936 |
ML2472 | ML0151 | gene:17576335 | gene:17573966 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | 0.946 |
ML2472 | aroA | gene:17576335 | gene:17574616 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.826 |
ML2472 | aroB | gene:17576335 | gene:17574339 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.833 |
ML2472 | aroF | gene:17576335 | gene:17574337 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.880 |
ML2472 | aroK | gene:17576335 | gene:17574338 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.710 |
ML2472 | trpE | gene:17576335 | gene:17575101 | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.485 |
aroA | ML0151 | gene:17574616 | gene:17573966 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | 0.697 |
aroA | ML2472 | gene:17574616 | gene:17576335 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. | 0.826 |
aroA | aroB | gene:17574616 | gene:17574339 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.986 |
aroA | aroD | gene:17574616 | gene:17574340 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.484 |
aroA | aroE | gene:17574616 | gene:17574336 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | 0.997 |
aroA | aroF | gene:17574616 | gene:17574337 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.993 |
aroA | aroK | gene:17574616 | gene:17574338 | Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.982 |