STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
aroBPutative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (361 aa)    
Predicted Functional Partners:
aroK
Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.999
aroD
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
 0.998
aroE
Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase.
  
 0.996
aroF
Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.996
aroA
Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.986
aroG
Identical to the previously sequenced Mycobacterium leprae 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O69569 (EMBL:AL022602) (462 aa); Fasta score E(): 0, 100.0% identity in 462 aa overlap(EMBL:AL022602). Also highly similar to many others e.g. Mycobacterium tuberculosis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase TR:O53512 (EMBL:AL021957) (462 aa); Fasta score E(): 0, 89.7% identity in 465 aa overlap(EMBL:AL021957) and similar to many plant DAHP synthetase family proteins e.g. Arabidopsis thaliana SW:AROF_ARATH (SW:P29976) (525 aa); Fasta score E(): 0, 49.0% iden [...]
 
  
 0.979
ML2472
Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase.
 
  
 0.833
ML0258
Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434.
 
 
    0.655
pheA
Putative prephenate dehydratase; Similar to M. tuberculosis Rv3838c, pheA, prephenate dehydratase, TR:P96240 (EMBL:AL123456) (321 aa); Fasta score E(): 0, 83.9% identity in 311 aa overlap. Similar to Amycolatopsis methanolica pheA, prephenate dehydratase, SW:PHEA_AMYME (Q44104) (304 aa); Fasta score E(): 0, 44.4% identity in 315 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase. Contains PS00858 Prephenate dehydratase signature 2.
 
  
 0.626
hisC
Highly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II.
  
  
 0.614
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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