node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argF | carA | gene:17575249 | gene:17574356 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | 0.965 |
argF | carB | gene:17575249 | gene:17574357 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | 0.995 |
argF | gltB | gene:17575249 | gene:17573873 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.650 |
argF | pyrB | gene:17575249 | gene:17574353 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] | 0.847 |
argF | pyrC | gene:17575249 | gene:17574354 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.436 |
carA | argF | gene:17574356 | gene:17575249 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.965 |
carA | carB | gene:17574356 | gene:17574357 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | 0.999 |
carA | glnA | gene:17574356 | gene:17574751 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score E(): 0, 91.8% identity in 478 aa overlap and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature; Similar to ML1631. | 0.911 |
carA | glnA2 | gene:17574356 | gene:17575472 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Glutamine synthase class II; Highly similar to many glutamine synthetases (EC 6.3.1.2) including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa); Fasta score E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis RV2222C SW:GLN2_MYCTU (Q10378) (446 aa); Fasta score E(): 0, 93.3% identity in 448 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase; Similar to ML0925. | 0.911 |
carA | gltB | gene:17574356 | gene:17573873 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.947 |
carA | purF | gene:17574356 | gene:17576063 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.948 |
carA | purQ | gene:17574356 | gene:17576076 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.937 |
carA | pyrB | gene:17574356 | gene:17574353 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] | 0.999 |
carA | pyrC | gene:17574356 | gene:17574354 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.996 |
carA | pyrF | gene:17574356 | gene:17574358 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.966 |
carB | argF | gene:17574357 | gene:17575249 | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.995 |
carB | carA | gene:17574357 | gene:17574356 | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | 0.999 |
carB | glnA | gene:17574357 | gene:17574751 | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score E(): 0, 91.8% identity in 478 aa overlap and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature; Similar to ML1631. | 0.909 |
carB | glnA2 | gene:17574357 | gene:17575472 | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | Glutamine synthase class II; Highly similar to many glutamine synthetases (EC 6.3.1.2) including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa); Fasta score E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis RV2222C SW:GLN2_MYCTU (Q10378) (446 aa); Fasta score E(): 0, 93.3% identity in 448 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase; Similar to ML0925. | 0.909 |
carB | gltB | gene:17574357 | gene:17573873 | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.990 |