node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1591 | carA | gene:17575432 | gene:17574356 | Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | 0.751 |
ML1591 | gmk | gene:17575432 | gene:17574362 | Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.587 |
ML1591 | pyrF | gene:17575432 | gene:17574358 | Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.930 |
ML1889 | pyrF | gene:17575737 | gene:17574358 | Putataive endonuclease IV (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.933 |
ML2487 | ML2489 | gene:17576351 | gene:17576353 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | 0.493 |
ML2487 | carA | gene:17576351 | gene:17574356 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | 0.677 |
ML2487 | carB | gene:17576351 | gene:17574357 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | 0.713 |
ML2487 | pyrB | gene:17576351 | gene:17574353 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] | 0.832 |
ML2487 | pyrC | gene:17576351 | gene:17574354 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.847 |
ML2487 | pyrD | gene:17576351 | gene:17575127 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.985 |
ML2487 | pyrF | gene:17576351 | gene:17574358 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.992 |
ML2489 | ML2487 | gene:17576353 | gene:17576351 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.493 |
ML2489 | carA | gene:17576353 | gene:17574356 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | 0.670 |
ML2489 | carB | gene:17576353 | gene:17574357 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. | 0.707 |
ML2489 | pyrB | gene:17576353 | gene:17574353 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] | 0.726 |
ML2489 | pyrC | gene:17576353 | gene:17574354 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.726 |
ML2489 | pyrD | gene:17576353 | gene:17575127 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.750 |
ML2489 | pyrF | gene:17576353 | gene:17574358 | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence. | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.730 |
carA | ML1591 | gene:17574356 | gene:17575432 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.751 |
carA | ML2487 | gene:17574356 | gene:17576351 | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.677 |