STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkPutative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa)    
Predicted Functional Partners:
ML0542
Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
  
  
 0.990
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.970
hpt
Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...]
  
  
 0.959
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.931
relA
Putative GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).
  
 
 0.913
pykA
Pyruvate kinase; Highly similar to many pyruvate kinases (EC 2.7.1.40) including: Mycobacterium tuberculosis RV1617 SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature.
  
 
 0.912
nrdE
Ribonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
     
 0.907
nrdF
Ribonucleotide reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
     
 0.904
aroE
Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase.
  
 
 0.875
tpi
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
   
 0.855
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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