node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0542 | gmk | gene:17574363 | gene:17574362 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.990 |
ML0542 | pykA | gene:17574363 | gene:17575109 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Pyruvate kinase; Highly similar to many pyruvate kinases (EC 2.7.1.40) including: Mycobacterium tuberculosis RV1617 SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature. | 0.432 |
aroE | gmk | gene:17574336 | gene:17574362 | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.875 |
aroE | guaA | gene:17574336 | gene:17574214 | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.709 |
aroE | tpi | gene:17574336 | gene:17574393 | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.796 |
gmk | ML0542 | gene:17574362 | gene:17574363 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.990 |
gmk | aroE | gene:17574362 | gene:17574336 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | 0.875 |
gmk | guaA | gene:17574362 | gene:17574214 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.970 |
gmk | hpt | gene:17574362 | gene:17574031 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...] | 0.959 |
gmk | ndk | gene:17574362 | gene:17575307 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.931 |
gmk | nrdE | gene:17574362 | gene:17575579 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.907 |
gmk | nrdF | gene:17574362 | gene:17575576 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonucleotide reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.904 |
gmk | pykA | gene:17574362 | gene:17575109 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Highly similar to many pyruvate kinases (EC 2.7.1.40) including: Mycobacterium tuberculosis RV1617 SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature. | 0.912 |
gmk | relA | gene:17574362 | gene:17574312 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). | 0.913 |
gmk | tpi | gene:17574362 | gene:17574393 | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.855 |
guaA | aroE | gene:17574214 | gene:17574336 | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | Similar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. | 0.709 |
guaA | gmk | gene:17574214 | gene:17574362 | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.970 |
guaA | hpt | gene:17574214 | gene:17574031 | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...] | 0.962 |
guaA | ndk | gene:17574214 | gene:17575307 | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.590 |
guaA | nrdE | gene:17574214 | gene:17575579 | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ribonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.574 |