STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgkPhosphoglycerate kinase; Similar to M. tuberculosis pgk, Rv1437, phosphoglycerate kinase, SW:PGK_MYCTU (O06821) (412 aa); Fasta score E(): 0, 80.6% identity in 412 aa overlap. Similar to many e.g. Corynebacterium glutamicum pgk, phosphoglycerate kinase, SW:PGK_CORGL (Q01655) (403 aa); Fasta score E(): 0, 59.2% identity in 407 aa overlap. Previously sequenced as SW:PGK_MYCLE (P46712) (416 aa); Fasta score E(): 0, 99.8% identity in 416 aa overlap. Contains Pfam match to entry PF00162 PGK, Phosphoglycerate kinases. Contains PS00111 Phosphoglycerate kinase signature. (416 aa)    
Predicted Functional Partners:
gap
Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
 0.999
tpi
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 0.999
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 
 0.986
gpm
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
   
 0.983
pgi
Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2.
  
 
 0.925
pykA
Pyruvate kinase; Highly similar to many pyruvate kinases (EC 2.7.1.40) including: Mycobacterium tuberculosis RV1617 SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature.
 
 
 0.924
fba
Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
  
 
 0.888
ML0573
Hypothetical protein; Unknown function. Previously sequenced as TR:Q49684 (EMBL:U00013) (91 aa); Fasta score E(): 0, 98.9% identity in 91 aa overlap. Contains Pfam match to entry PF00121 TIM, Triosephosphate isomerase.
       0.773
ML0574
Hypothetical protein; Unknown function. Previously sequenced as TR:Q49680 (EMBL:U00013) (105 aa); Fasta score E(): 0, 99.0% identity in 105 aa overlap.
       0.773
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.693
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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