STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0640Conserved hypothetical protein; Similar to M. tuberculosis Rv3197, putative ABC transporter, TR:O53343 (EMBL:AL123456) (447 aa); Fasta score E(): 0, 83.0% identity in 447 aa overlap. Similar to many ABC1-like hypothetical proteins from bacteria and eukaryotes. Similar to Saccharomyces cerevisiae ABC1, ABC1 protein precursor, SW:ABC1_YEAST (P27697) (501 aa); Fasta score E(): 7.3e-19, 24.9% identity in 382 aa overlap. Previously sequenced as TR:Q49747 (EMBL:U00016) (267 aa); Fasta score E(): 0, 99.6% identity in 248 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Simi [...] (473 aa)    
Predicted Functional Partners:
ML0889
Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein TR:O53519 (EMBL:AL021957) (144 aa); Fasta score E(): 0, 84.7% identity in 144 aa overlap (EMBL:AL021957) (144 aa); Fasta score E(): 0, 84.7% identity in 144 aa overlap(EMBL:AL021957). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53519(EMBL:AL021957).
  
 
 
 0.743
ML2427
Similar to Mycobacterium tuberculosis hypothetical protein Rv0502 SW:Y502_MYCTU (Q11167) (358 aa) fasta scores: E(): 0, 85.2% id in 359 aa. Contains a Pfam match to PF01553 Acyltransferase. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase; To M.tuberculosis Rv0502.
  
     0.550
ML2306
Probable anion transporter protein; Similar to Mycobacterium tuberculosis putative anion transporting ATPase Rv3680 TR:O69648 (EMBL:AL022121) (386 aa) fasta scores: E(): 0, 88.1% id in 370 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA35 (EMBL:AL079353) (481 aa) fasta scores: E(): 0, 48.6% id in 432 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
  
     0.497
ML0642
Similar to M. tuberculosis Rv3195, conserved hypothetical protein, TR:O53341 (EMBL:AL123456) (472 aa); Fasta score E(): 0, 79.2% identity in 475 aa overlap. Similar to Streptomyces coelicolor SCE9.14C, hypothetical protein, TR:Q9X8I7 (EMBL:AL049841) (375 aa); Fasta score E(): 4.9e-12, 24.9% identity in 305 aa overlap. previously sequenced as TR:Q49746 (EMBL:U00016) (479 aa); Fasta score E(): 0, 99.8% identity in 479 aa overlap.
       0.483
ML2428
Possible glucose epimerase/dehydratase; Similar to Mycobacterium tuberculosis UDP-glucose 4-epimerase Rv0501 SW:Y501_MYCTU (Q11166) (376 aa) fasta scores: E(): 0, 84.0% id in 368 aa, and to Streptomyces violaceoruber dTDP-glucose dehydratase TR:Q56173 (EMBL:L37334) (321 aa) fasta scores: E(): 2.9e-07, 30.4% id in 332 aa.
 
    0.471
lipG
Probable hydrolase; Similar to M. tuberculosis putative hydrolase Rv0646c TR:P96935 (EMBL:Z92772) (301 aa); Fasta score E(): 0, 71.3% identity in 303 aa overlap, and to others e.g. Escherichia coli macrolide 2'-phosphotransferase II TR:P77026 (EMBL:D85892) (279 aa); Fasta score E(): 1.3e-15, 31.3% identity in 291 aa overlap, and Streptomyces peucetius 10-carbomethoxy-13-deoxycarminomycin esterase TR:Q54809 (EMBL:L40425) (298 aa); Fasta score E(): 1e-09, 28.6% identity in 301 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; Similar to and ML0862.
  
  
 0.460
ML2305
Probable anion transporter protein; Similar to Mycobacterium tuberculosis putative ATPase Rv3679 SW:Y0H9_MYCTU (O69647) (340 aa) fasta scores: E(): 0, 84.2% id in 341 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA36 (EMBL:AL079353) (325 aa) fasta scores: E(): 0, 52.4% id in 330 aa.
  
     0.443
ML2442
Similar to Mycobacterium tuberculosis hypothetical protein Rv0487 SW:Y487_MYCTU (Q11153) (183 aa) fasta scores: E(): 0, 69.2% id in 172 aa; To M.tuberculosis Rv0487.
  
     0.418
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.