STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
fprAPutative NADPH-ferredoxin reductase; May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family. (456 aa)    
Predicted Functional Partners:
gltB
Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
  
 
 0.999
fprB
Ferredoxin, ferredoxin-NADP reductase; Similar to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase SW:FPRB_MYCTU (Q10547) fasta scores: E(): 0, 76.6% in 560 aa, and to Homo sapiens NADPH:adrenodoxin oxidoreductase precursor SW:ADRO_HUMAN (P22570; Q13716) fasta scores: E(): 2.9e-30, 37.4% in 484 aa. Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00198 4Fe-4S ferredoxins.
 
0.948
fdxA
Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
 
 
 0.907
prfB
Putative peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
       0.727
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
     
 0.623
eftB
Electron transfer flavoprotein [beta] subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
  
 
 0.529
ML2088
Putative cytochrome p450; Similar to Streptomyces coelicolor putative cytochrome p-450 hydroxylase TR:Q9X8Q3 (EMBL:AL049754) fasta scores: E(): 0, 37.4% in 401 aa, and to Mycobacterium tuberculosis putative cytochrome p450 rv1880c SW:YI80_MYCTU (O08464) fasta scores: E(): 0, 38.0% in 416 aa, and to Bacillus subtilis biotin biosynthesis; cytochrome p450-like enzyme SW:BIOI_BACSU (P53554) fasta scores: E(): 0, 37.1% in 383 aa. Contains Pfam match to entry PF00067 p450, Cytochrome P450.
 
   
 0.502
eftA
Electron transfer flavoprotein [alpha] subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
  
 
 0.455
ML0447
Hypothetical protein; Similar to region of cytochrome P450s e.g. Bacillus megaterium CYP102A1, cytochrome P450(BM-3), SW:CPXB_BACME (P14779) (1048 aa); Fasta score E(): 0.00033, 31.8% identity in 132 aa overlap. previously sequenced as TR:O07142 (EMBL:Z96801) (126 aa); Fasta score E(): 0, 99.2% identity in 126 aa overlap.
     
 0.434
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 
 0.426
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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