STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
addPutative adenosine deaminase; Similar to M. tuberculosis add, Rv3313c, probable adenosine deaminase, TR:O53365 (EMBL:AL123456) (365 aa); Fasta score E(): 0, 88.2% identity in 356 aa overlap. Similar to many e.g. Escherichia coli add, adenosine deaminase, SW:ADD_ECOLI (P22333) (333 aa); Fasta score E(): 6.8e-19, 29.7% identity in 340 aa overlap. Previously sequenced as TR:Q49907 (EMBL:U00022) (332 aa); Fasta score E(): 0, 99.7% identity in 332 aa overlap. Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. A [...] (362 aa)    
Predicted Functional Partners:
ML0873
Putative carbohydrate kinase; Similar to Mycobacterium tuberculosis hypothetical sugar kinase Rv2202c or MTCY190.13C SW:YM02_MYCTU (Q10391) (324 aa) fasta scores: E(): 0, 83.3% id in 324 aa, and to Streptomyces coelicolor putative kinase SC6G10.31C TR:Q9X816 (EMBL:AL049497) (338 aa) fasta scores: E(): 0, 58.9% id in 319 aa. Shows weak similarity to known kinases e.g. Bacillus subtilis ribokinase rbsK SW:RBSK_BACSU (P36945; P96733) (293 aa) fasta scores: E(): 1.2e-07, 26.1% id in 283 aa. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase. Contains PS00583 pfkB fa [...]
   
 0.978
deoD
Putative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
  
 
 0.929
adk
Probable adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
   
  
 0.729
sdhC
Similar to M. tuberculosis sdhC, Rv3316, putative membrane anchor of succinate dehydrogenase, TR:O53368 (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% identity in 112 aa overlap. Similar to many e.g. Escherichia coli sdhC, succinate dehydrogenase cytochrome B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): 0.074, 24.3% identity in 136 aa overlap. Previously sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit.
  
   0.707
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
   
 0.704
sdhD
Similar to M. tuberculosis sdhD, Rv3317, putative membrane anchor of succinate dehydrogenase, TR:O53369 (EMBL:AL123456) (144 aa); Fasta score E(): 0, 85.2% identity in 142 aa overlap. Shows weak similarity to e.g. Rickettsia prowazekii sdhD, succinate dehydrogenase hydrophobic membrane anchor protein, SW:DHSD_RICPR (P41086) (125 aa); Fasta score E(): 0.24, 26.7% identity in 105 aa overlap. Previously sequenced as TR:Q49915 (EMBL:U00022) (163 aa); Fasta score E(): 0, 100.0% identity in 163 aa overlap.Contains hydrophobic, possible membrane-spanning regions.
       0.681
sdhB
Similar to M. tuberculosis sdhB, Rv3319, succinate dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. Similar to many e.g. Escherichia coli sdhB, succinate dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur b [...]
  
    0.673
sdhA
Similar to M. tuberculosis sdhA, Rv3318, succinate dehydrogenase subunit A, TR:O53370 (EMBL:AL123456) (590 aa); Fasta score E(): 0, 92.5% identity in 590 aa overlap. Similar to many e.g. Escherichia coli sdhA, succinate dehydrogenase flavoprotein subunit, SW:DHSA_ECOLI (P10444) (588 aa); Fasta score E(): 0, 48.6% identity in 589 aa overlap. Previously sequenced as TR:Q49924 (EMBL:U00022) (401 aa); Fasta score E(): 0, 97.2% identity in 395 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD [...]
  
    0.672
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.610
purA
Putative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.535
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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