STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
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[Homology]
Score
deoDPutative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine. (268 aa)    
Predicted Functional Partners:
pmmB
Putative phospho-sugar mutase; Similar to M. tuberculosis pmmB, putative phosphomannomutase, TR:O53360 (EMBL:AL123456) (534 aa); Fasta score E(): 0, 76.8% identity in 538 aa overlap. Similar to many putative phospho-sugar mutases and to Streptococcus pneumoniae pgm, phosphoglucomutase involved in type 3 capsule production and basic metabolism, TR:Q9RP94 (EMBL:AF165218) (572 aa); Fasta score E(): 1.4e-19, 32.6% identity in 549 aa overlap. Previously sequenced as TR:Q49913 (EMBL:U00022) (534 aa); Fasta score E(): 0, 99.8% identity in 534 aa overlap. Contains Pfam match to entry PF00408 P [...]
 
 
 0.963
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
 
  0.935
hpt
Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...]
  
 0.934
add
Putative adenosine deaminase; Similar to M. tuberculosis add, Rv3313c, probable adenosine deaminase, TR:O53365 (EMBL:AL123456) (365 aa); Fasta score E(): 0, 88.2% identity in 356 aa overlap. Similar to many e.g. Escherichia coli add, adenosine deaminase, SW:ADD_ECOLI (P22333) (333 aa); Fasta score E(): 6.8e-19, 29.7% identity in 340 aa overlap. Previously sequenced as TR:Q49907 (EMBL:U00022) (332 aa); Fasta score E(): 0, 99.7% identity in 332 aa overlap. Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. A [...]
  
 
 0.929
ML0873
Putative carbohydrate kinase; Similar to Mycobacterium tuberculosis hypothetical sugar kinase Rv2202c or MTCY190.13C SW:YM02_MYCTU (Q10391) (324 aa) fasta scores: E(): 0, 83.3% id in 324 aa, and to Streptomyces coelicolor putative kinase SC6G10.31C TR:Q9X816 (EMBL:AL049497) (338 aa) fasta scores: E(): 0, 58.9% id in 319 aa. Shows weak similarity to known kinases e.g. Bacillus subtilis ribokinase rbsK SW:RBSK_BACSU (P36945; P96733) (293 aa) fasta scores: E(): 1.2e-07, 26.1% id in 283 aa. Contains Pfam match to entry PF00294 pfkB, pfkB family carbohydrate kinase. Contains PS00583 pfkB fa [...]
  
 0.929
ML1511
Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily.
    
 0.905
dgt
Similar to Mycobacterium tuberculosis deoxyguanosinetriphosphate triphosphohydrolase dgt or Rv2344c or MTCY98.13c SW:DGTP_MYCTU (P95240) (431 aa) fasta scores: E(): 0, 83.8% id in 421 aa and to many hypothetical deoxyguanosine hydrolases. Contains Pfam match to entry PF01966 HD, HD domain; Belongs to the dGTPase family. Type 2 subfamily.
    
  0.900
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.557
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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